I found some clinical trials that had demonstrated effect…
Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial.
Ritsner MS1, Bawakny H, Kreinin A.
Neuroscience. 2011 Sep 15;191:78-90. doi: 10.1016/j.neuroscience.2011.06.076. Epub 2011 Jul 1. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.
Marx CE1, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD.
Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial.
Ritsner MS, Gibel A, Shleifer T, Boguslavsky I, Zayed A, Maayan R, Weizman A, Lerner V.
J Clin Psychiatry. 2010 Oct;71(10):1351-62. doi: 10.4088/JCP.09m05031yel. Epub 2010 Jun 15.
Pregnenolone for cognition and mood in dual diagnosis patients.
Osuji IJ, Vera-Bolaños E, Carmody TJ, Brown ES.
Psychiatry Res. 2010 Jul 30;178(2):309-12. doi: 10.1016/j.psychres.2009.09.006. Epub 2010 May 21.
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
Marx CE, Keefe RS, Buchanan RW, Hamer RM, Kilts JD, Bradford DW, Strauss JL, Naylor JC, Payne VM, Lieberman JA, Savitz AJ, Leimone LA, Dunn L, Porcu P, Morrow AL, Shampine LJ.
Neuropsychopharmacology. 2009 Jul;34(8):1885-903. doi: 10.1038/npp.2009.26. Epub 2009 Apr 1.
Additionally, I also found these journal articles…
The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2±dependent mechanism.
Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH.
Mol Pharmacol. 2013 Aug;84(2):261-74. doi: 10.1124/mol.113.085696. Epub 2013 May 28.
A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons.
Kostakis E, Jang MK, Russek SJ, Gibbs TT, Farb DH.
J Neurochem. 2011 Nov;119(3):486-96. doi: 10.1111/j.1471-4159.2011.07442.x. Epub 2011 Sep 28.
Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.
Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD.
Neuroscience. 2011 Sep 15;191:78-90. doi: 10.1016/j.neuroscience.2011.06.076. Epub 2011 Jul 1. Review.
The clinical and therapeutic potentials of dehydroepiandrosterone and pregnenolone in schizophrenia.
Neuroscience. 2011 Sep 15;191:91-100. doi: 10.1016/j.neuroscience.2011.04.017. Epub 2011 Apr 24. Review.
Pregnenolone, dehydroepiandrosterone, and schizophrenia: alterations and clinical trials.
CNS Neurosci Ther. 2010 Spring;16(1):32-44. doi: 10.1111/j.1755-5949.2009.00118.x. Review.
Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.
Whittaker MT, Gibbs TT, Farb DH.
J Neurochem. 2008 Oct;107(2):510-21. doi: 10.1111/j.1471-4159.2008.05627.x. Epub 2008 Aug 14.
Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects.
Ritsner M, Maayan R, Gibel A, Weizman A.
Eur Neuropsychopharmacol. 2007 Apr;17(5):358-65. Epub 2006 Nov 21.
Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?
Marx CE, Shampine LJ, Duncan GE, VanDoren MJ, Grobin AC, Massing MW, Madison RD, Bradford DW, Butterfield MI, Lieberman JA, Morrow AL.
Pharmacol Biochem Behav. 2006 Aug;84(4):598-608. Epub 2006 Sep 8.
Gee, I wonder about calling this hormone a vitamin. I gather Vitamin D is a hormone, however.
Well, I know who to ask about Pregnenolone. Specifically, I go to a specialist in OTC nutrients for schizophrenia, although his practice has been turned upside down by all the cancer patients who clearly demonstrated that his stuff saves lives; schizophrenics like myself have to deal with stuff like, “Well, you probably were misdiagnosed when they labeled you schizophrenic.” Yeah, and I was surely misdiagnosed when they locked me up against my will for nearly two years in mental hospitals; now I’ve lived independently for greater than 30 years.
I think this is a hormone that occurs naturally in the body. I would be wary of upping the amount because it is a hormone… Though the good effects would be tempting. I would probably not try it until it was tested by time.
I read good things about Pregnenolone and decided to try it over a year ago. I took half of the pill, which was a total of 25 mg. I felt a bit lightheaded after it. The reason I didn’t take it anymore is because I couldn’t read after I took it, this effect went away luckily. I first got the side-effect of not being able to read after I took a high dose of Piracetam for some time. After that I have gotten it also from fish oil and Licorice root, with varying degrees of severity. I did like how it made me feel overall, it helped my akathisia a lot and negative symptoms were better. I think I still have it so I might try it again but I doubt I will have a different response, I know that’s just me and almost everybody else doesn’t get the effect on their ability to read.
Hi - you can just buy it online. I like to use the Google Shopping Search engine - here is the link/search - just click on it and you can see where you can buy the products. You need to take 50mg a day says the study.
This drug is a steroid. I take steroids off and on to treat asthma and RA. They are horrible albeit lifesaving drugs. It is dangerous to take steroids long term. They negatively affect immunity and caused thinning of the skin as well as disrupt sleep and cause excessive weight gain. I am currently taking Medrol - a steroid for RA and am suffering from all its effects. I wonder if Medrol and Prednisone help negative symptoms. I know that steroids can cause psychosis. I have had problems with that when taking higher doses. I would want some of these questions answered before I would agree to take it.