Sarcosine Researcher Interview - Your Questions Please

Does sarcosine really works?
Bitopertin that works totally similiar to Sarcosine had failed the clinical trial,how is Sarcosine be able to work?

Had tried Three different brand of Sarcosine
Smart powder
Pure sarcosine
And one more brand which I forgotten the name.If the old forum is accessible,i had post a few log about Sarcosine,didn’t work out for me : (

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Poisonpencil?
@poisenpencil
I hope your the old person in the previous forum.Do you remember me?Mobc1990 from the old forum?we talked about Sarcosine,Glycine on the forum and also private message?

How are you doing?what meds are you on?Its been I believe three years since we last contacted :smile:

I think the answer may be that Bitopertin was a different molecule / substance that was targeting the same brain receptor (NMDA) that sarcosine impacts. Because its a different substance, its not surprising that the results might be different from that experienced with sarcosine.

Just like there are many of the “atypical antipsychotics” that target the 5-HT (serotonin) receptors in the brain - and each of these drugs impact people differently.

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its both Glycine Transporter 1 Inhibitor (GlyT1 Inhiibitor)

anyway I had tried sarcosine for a month(longest time),it didn’t work for me,i took 1.5 mg twice a day

Dmar also tried the smartpowders sarcosine without success - then tried the sarcosine from another company and had success. I don’t think that you can assume that sarcosine from one supplier is the same as that from all the other suppliers. This is true for all supplements I think - they vary in quality and purity just like with any product (perhaps even more true with supplements).

alright…thank you for information…would follow news on Sarcosine closely :smile:

If you want to chat PM me. Or I’ll PM you. Whichever materializes first.

Can sarcosine induce mania or hypo-mania in someone with sza/bipolar type? I had this problem with another hormone type substance that was recommended by sz/admin. I don’t remember the name of it now. I noticed that you said that sarcosine elevates mood in those with schizophrenia. So, maybe sza/bipolar’s shouldn’t take it?

Buy it from brainvitaminz

Hi Gina,

I don’t know if anyone has studied sarcosine in sza / bipolar people - I haven’t seen any research in this area. Also - we don’t “recommend” any vitamins or supplements here - we just say that there is research that suggests that some of these might be helpful. I think you had issues with Pregnenolone - is that right? Whatever the case - I recommend you discuss it with your doctor, and also with sarcosine.

Here is the only negative reaction I’ve seen to sarcosine - a type of “irritabilty” with higher levels (2 grams+) in one person (this is part of a larger study, I believe, so nobody else had this reaction - so I guess its quite rare).

See this paper:

“we started administration of 2 g of sarcosine per day to treat persistent negative and cognitive symptoms. The patient’s activity and mood improved within 2 weeks, but in the following 2 weeks the patient reported increased drive, activity, libido, unpleasant inner tension, and irritability. We ruled out hypomania and decided to decrease the daily dose of sarcosine to 1 g, which resulted in reduction of drive and irritability. Activity and mood improved compared with his state before adding sarcosine.”

Source:

Also - was this the other supplement you tried?

Sarcosine is supposed to increase testosterone production, are there any contraindications for women taking the amino acid over extended periods?

What is the efficacy of synthetic sarcosine versus the efficacy of organic sarcosine? Has there been any research on that?

I think this is wrong. I searched on Pubmed.org for information on this and can’t find a single medical study that suggests that sarcosine increases testosterone.

The only place where you find statements about this are on bodybuilding supplement sites - who are selling stuff to young males who generally tend to think that they need more testosterone - so its a sales promotion technique. Unless you can find a scientific reference to sarcosine increasing testosterone - I think this is just marketing misinformation.

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The researchers I’ve talked to suggested all sarcosine people buy today is manufactured (not distilled from animal flesh - which would be very expensive I guess). Have never seen any references to “organic” sarcosine.

What is the word on sarcosine and increased risk of prostate cancer ? I have seen several articles mentioning sarcosine and prostate. Would it be safe to take if at increased risk of prostate problems?

This had been worrying me. Thanks for reassuring me.

This is what I have seen on this topic - basically its going to take a number of years before the research has a better understanding on this. if you’re an older male (I think prostate cancer screening typically begins around age 50 or 55 in most developed countries) - I’d probably avoid long terms sarcosine supplementation until more information becomes available - just to be on the safe side.

Sarcosine is being investigated for its connection to prostate cancer. It may be a biomarker for prostate cancer, which means that if sarcosine levels in the blood are higher than normal, it could be an indicator of prostate cancer. This doesn’t mean that sarcosine itself causes cancer. More research is needed to confirm this relationship.

Source:

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Can you become dependent on it? Like if you take it for awhile and then stop do you suddenly need it even more than before? Are there withdrawals?

Thanks for responding back. Yes, I did try pregnenelone. It caused me to become inappropriate in behavior, which is a sign of mania for me. I had to go on Seroquel because of it. I tend to be an irritable-angry manic, so I’m understandably hesitant to take sarcosine.

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You asked another question: If I noticed any positive benefits from pregnenelone. I’m sorry, but I don’t remember any positive effects. (Not to say I didn’t have any.)

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