Just saying hi!

Persephone · December 3, 2016, 5:28pm

Hi there,

I am diagnosed schizophrenic after a long 3 year bout of meth induced psychosis. I have been clean ever since the symptoms presented back in December of 2013. My doctor and I think that I “opened the door” to schizophrenia by doing that horrible drug. Anyway, the last 3 years have been crazy and finally with the proper medication I have gotten ahold of it. I’ve tried all sorts of stuff from clozapate to risperdal to quetiapine, zyprexa, and more. None of the stuff seemed to help. I’m now on Latuda and Clonazepam along with a nootropic stack and my voices have finally taken the back seat in my life!! It’s like a miracle. My nootropic stack consists of NAC, Sarcosine, a Magnesium Supplement, and L-Theanine. Never did I think I’d make it back from the brink but I finally have. If anyone has any questions regarding my stack, let me know, I’d be happy to share.

far_cry0 · December 3, 2016, 5:33pm

which supplement do u take now that benefits U…??

Loke · December 3, 2016, 5:37pm

I take melatonin. It helps me sleep.

Persephone · December 3, 2016, 5:58pm

I take something called ZMA powder from PowderCity. Http://www.powdercity.com . It’s kind of a silly name, but they are my go to for Nootropics.

ZMA powder consists of Zinc, Magnesium, and Vitamin B6.

far_cry0 · December 3, 2016, 6:00pm

What about Sarcosine Ltheanine and vitamin Pregnenolone…
these stuff are for negative symptoms…

Persephone · December 3, 2016, 6:02pm

I take the Sarcosine and L-Theanine , but I haven’t tried the pregnenolone. I’ll order some and give it a shot!

You can get all this stuff from PowderCity. I’m sure there’s other vendors, thats just the one I use.

far_cry0 · December 3, 2016, 6:03pm

yes update us…
I am soon going to use all three…!!!

everhopeful · December 3, 2016, 6:33pm

Be very careful with pregnenolone. I wouldn’t take it myself.

There isn’t enough information to know if pregnenolone is safe when taken by mouth. It might cause some steroid-like side effects including overstimulation, insomnia, irritability, anger, anxiety, acne, headache, negative mood changes, facial hair growth, hair loss, and irregular heart rhythm.
Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of pregnenolone during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Pregnenolone is converted by the body to estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t take supplemental pregnenolone.

far_cry0 · December 3, 2016, 6:39pm

ncbi.nlm.nih.gov

Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.

CE Marx, DW Bradford, RM Hamer, JC Naylor, TB Allen, JA Lieberman, JL Strauss and JD Kilts, Neuroscience, Sep 2011 15

Emerging preclinical and clinical evidence suggests that pregnenolone may be a promising novel therapeutic candidate in schizophrenia. Pregnenolone is a neurosteroid with pleiotropic actions in rodents that include the enhancement of learning and memory, neuritic outgrowth, and myelination. Further, pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. In addition, pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors. There are thus multiple mechanistic possibilities for pregnenolone as a potential therapeutic agent in schizophrenia, including the amelioration of NMDA receptor hypofunction (via metabolism to pregnenolone sulfate) and the mitigation of GABA dysregulation (via metabolism to allopregnanolone). Additional evidence consistent with a therapeutic role for pregnenolone in schizophrenia includes neurosteroid changes following administration of certain antipsychotics in rodent models. For example, clozapine elevates pregnenolone levels in rat hippocampus, and these increases may potentially contribute to its superior antipsychotic efficacy [Marx et al. (2006a) Pharmacol Biochem Behav 84:598-608]. Further, pregnenolone levels appear to be altered in postmortem brain tissue from patients with schizophrenia compared to control subjects [Marx et al. (2006c) Neuropsychopharmacology 31:1249-1263], suggesting that neurosteroid changes may play a role in the neurobiology of this disorder and/or its treatment. Although clinical trial data utilizing pregnenolone as a therapeutic agent in schizophrenia are currently limited, initial findings are encouraging. Treatment with adjunctive pregnenolone significantly decreased negative symptoms in patients with schizophrenia or schizoaffective disorder in a pilot proof-of-concept randomized controlled trial, and elevations in pregnenolone and allopregnanolone post-treatment with this intervention were correlated with cognitive improvements [Marx et al. (2009) Neuropsychopharmacology 34:1885-1903]. Another pilot randomized controlled trial recently presented at a scientific meeting demonstrated significant improvements in negative symptoms, verbal memory, and attention following treatment with adjunctive pregnenolone, in addition to enduring effects in a small subset of patients receiving pregnenolone longer-term [Savitz (2010) Society of Biological Psychiatry Annual Meeting New Orleans, LA]. A third pilot clinical trial reported significantly decreased positive symptoms and extrapyramidal side effects following adjunctive pregnenolone, in addition to increased attention and working memory performance [Ritsner et al. (2010) J Clin Psychiatry 71:1351-1362]. Future efforts in larger cohorts will be required to investigate pregnenolone as a possible therapeutic candidate in schizophrenia, but early efforts are promising and merit further investigation. This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain.

far_cry0 · December 3, 2016, 6:40pm

Vitamin Pregnenolone - New Treatment for Schizophrenia - anyone trying it? DX'd - Other

Please let me know if you have tried pregnenolone? What effects positive or negative have you noticed? If you haven’t tried it - perhaps try it and report back. I’ve read that it can be helpful in negative symptoms that are common in schizophrenia. The dosing in the top study was 50 mg per day. It can be purchased here (this link is a google shopping search: https://www.google.com/?gws_rd=ssl#q=Pregnenolone&safe=off&tbm=shop I found some clinical trials that had demonstrated effect… Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial. Ritsner MS1, Bawakny H, Kreinin A. Neuroscienc…

Daze · December 3, 2016, 6:44pm

Drug and alcohol withdrawal and change requires replacement therapy with health and food and lifestyle

Don’t count totally on prescription pills

far_cry0 · December 3, 2016, 6:44pm

U might be right Everhopefull …But Sz is more like death sentence to me…So i risk it with anything…
pregnenolone is kind of trusted by pubmed too …
so waiting for a viza…!!!

Persephone · December 3, 2016, 9:45pm

I originally got sober in a 12 step program, so I am very knowledgeable in recovery. Thanks though, I completely agree!

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Just saying hi!

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