Pregnenolone for schizophrenia

pregnenolone sulfate. have anyone tried this.its sodium salt (CAS 1852-38-6), is a GABA A receptor antagonist.to all my friends do research in this if it is good then just try it…thanks

I searched for it but I read it treated depression and anxiety maybe. It didn’t refer anything about sz.

There is some research on it:

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I 'm sorry @far_cry0, I just read about it in wikipedia, I believed what I read there was right, but I was wrong. You were right.

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@redrose no problem.

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@MichaelFin thanks 4 da valuable information…

@Erratica i just read about it as i am from asia(nepal) we dont have online shop.u can do a google research…thanks .have a good day…

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I tried 50 mg a day for about a week or two. It made me extremely irritable with both people I knew and with strangers. Very dangerous drug for people with mood problems. I had to go to my pdoc to get on an increased dose of Seroquel. He increased my dose by 100% Now, I am calm, and mild, and tranquil. Much more so than before.

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its iherb .com…u can find it there…

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We have had lots of info on this here: I don’t know about the “sulfate” version of it.

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There was a bunch of noise on two different medical websites today about new research on the role of the GABA receptors in sz. I am always cautious with such stuff when it points to some role for yet more (expensive) (profit-producing) medications, but do see how stress hormones tickling GABA receptors makes sense as having a piece of the etiological pie.

Journal References:

Janine Arloth, Ryan Bogdan, Peter Weber, Goar Frishman, Andreas Menke, Klaus V. Wagner, Georgia Balsevich, Mathias V. Schmidt, Nazanin Karbalai, Darina Czamara, Andre Altmann, Dietrich Trümbach, Wolfgang Wurst, Divya Mehta, Manfred Uhr, Torsten Klengel, Angelika Erhardt, Caitlin E. Carey, Emily Drabant Conley, Andreas Ruepp, Bertram Müller-Myhsok, Ahmad R. Hariri, Elisabeth B. Binder. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron, 2015; 86 (5): 1189 DOI: 10.1016/j.neuron.2015.05.034

Andrew J. Pocklington, Elliott Rees, James T.R. Walters, Jun Han, David H. Kavanagh, Kimberly D. Chambert, Peter Holmans, Jennifer L. Moran, Steven A. McCarroll, George Kirov, Michael C. O’Donovan, Michael J. Owen. Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia. Neuron, 2015; 86 (5): 1203 DOI: 10.1016/j.neuron.2015.04.022

Sien Braat, R. Frank Kooy. The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders. Neuron, 2015; 86 (5): 1119 DOI: 10.1016/j.neuron.2015.03.042