Pregnenolone for schizophrenia

far_cry0 · April 21, 2015, 7:43am

pregnenolone sulfate. have anyone tried this.its sodium salt (CAS 1852-38-6), is a GABA A receptor antagonist.to all my friends do research in this if it is good then just try it…thanks

redrose · April 21, 2015, 12:04pm

I searched for it but I read it treated depression and anxiety maybe. It didn’t refer anything about sz.

MichaelFin · April 21, 2015, 3:44pm

There is some research on it:

ncbi.nlm.nih.gov

Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.

CE Marx, DW Bradford, RM Hamer, JC Naylor, TB Allen, JA Lieberman, JL Strauss and JD Kilts, Neuroscience, Sep 2011 15

Emerging preclinical and clinical evidence suggests that pregnenolone may be a promising novel therapeutic candidate in schizophrenia. Pregnenolone is a neurosteroid with pleiotropic actions in rodents that include the enhancement of learning and memory, neuritic outgrowth, and myelination. Further, pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. In addition, pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors. There are thus multiple mechanistic possibilities for pregnenolone as a potential therapeutic agent in schizophrenia, including the amelioration of NMDA receptor hypofunction (via metabolism to pregnenolone sulfate) and the mitigation of GABA dysregulation (via metabolism to allopregnanolone). Additional evidence consistent with a therapeutic role for pregnenolone in schizophrenia includes neurosteroid changes following administration of certain antipsychotics in rodent models. For example, clozapine elevates pregnenolone levels in rat hippocampus, and these increases may potentially contribute to its superior antipsychotic efficacy [Marx et al. (2006a) Pharmacol Biochem Behav 84:598-608]. Further, pregnenolone levels appear to be altered in postmortem brain tissue from patients with schizophrenia compared to control subjects [Marx et al. (2006c) Neuropsychopharmacology 31:1249-1263], suggesting that neurosteroid changes may play a role in the neurobiology of this disorder and/or its treatment. Although clinical trial data utilizing pregnenolone as a therapeutic agent in schizophrenia are currently limited, initial findings are encouraging. Treatment with adjunctive pregnenolone significantly decreased negative symptoms in patients with schizophrenia or schizoaffective disorder in a pilot proof-of-concept randomized controlled trial, and elevations in pregnenolone and allopregnanolone post-treatment with this intervention were correlated with cognitive improvements [Marx et al. (2009) Neuropsychopharmacology 34:1885-1903]. Another pilot randomized controlled trial recently presented at a scientific meeting demonstrated significant improvements in negative symptoms, verbal memory, and attention following treatment with adjunctive pregnenolone, in addition to enduring effects in a small subset of patients receiving pregnenolone longer-term [Savitz (2010) Society of Biological Psychiatry Annual Meeting New Orleans, LA]. A third pilot clinical trial reported significantly decreased positive symptoms and extrapyramidal side effects following adjunctive pregnenolone, in addition to increased attention and working memory performance [Ritsner et al. (2010) J Clin Psychiatry 71:1351-1362]. Future efforts in larger cohorts will be required to investigate pregnenolone as a possible therapeutic candidate in schizophrenia, but early efforts are promising and merit further investigation. This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain.

redrose · April 21, 2015, 4:09pm

I 'm sorry @far_cry0, I just read about it in wikipedia, I believed what I read there was right, but I was wrong. You were right.

far_cry0 · April 22, 2015, 1:52am

@redrose no problem.

far_cry0 · April 22, 2015, 11:04am

@MichaelFin thanks 4 da valuable information…

far_cry0 · April 22, 2015, 11:13am

@Erratica i just read about it as i am from asia(nepal) we dont have online shop.u can do a google research…thanks .have a good day…

mylifeiswonderful68 · May 31, 2015, 6:28am

I tried 50 mg a day for about a week or two. It made me extremely irritable with both people I knew and with strangers. Very dangerous drug for people with mood problems. I had to go to my pdoc to get on an increased dose of Seroquel. He increased my dose by 100% Now, I am calm, and mild, and tranquil. Much more so than before.

far_cry0 · May 31, 2015, 6:41am

its iherb .com…u can find it there…

SzAdmin · June 6, 2015, 8:11pm

We have had lots of info on this here: I don’t know about the “sulfate” version of it.

Vitamin Pregnenolone - New Treatment for Schizophrenia - anyone trying it? DX'd - Other

Please let me know if you have tried pregnenolone? What effects positive or negative have you noticed? If you haven’t tried it - perhaps try it and report back. I’ve read that it can be helpful in negative symptoms that are common in schizophrenia. The dosing in the top study was 50 mg per day. It can be purchased here (this link is a google shopping search: https://www.google.com/?gws_rd=ssl#q=Pregnenolone&safe=off&tbm=shop I found some clinical trials that had demonstrated effect… Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial. Ritsner MS1, Bawakny H, Kreinin A. Neuroscienc…

notmoses · June 6, 2015, 9:14pm

There was a bunch of noise on two different medical websites today about new research on the role of the GABA receptors in sz. I am always cautious with such stuff when it points to some role for yet more (expensive) (profit-producing) medications, but do see how stress hormones tickling GABA receptors makes sense as having a piece of the etiological pie.

Journal References:

Janine Arloth, Ryan Bogdan, Peter Weber, Goar Frishman, Andreas Menke, Klaus V. Wagner, Georgia Balsevich, Mathias V. Schmidt, Nazanin Karbalai, Darina Czamara, Andre Altmann, Dietrich Trümbach, Wolfgang Wurst, Divya Mehta, Manfred Uhr, Torsten Klengel, Angelika Erhardt, Caitlin E. Carey, Emily Drabant Conley, Andreas Ruepp, Bertram Müller-Myhsok, Ahmad R. Hariri, Elisabeth B. Binder. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron, 2015; 86 (5): 1189 DOI: 10.1016/j.neuron.2015.05.034

Andrew J. Pocklington, Elliott Rees, James T.R. Walters, Jun Han, David H. Kavanagh, Kimberly D. Chambert, Peter Holmans, Jennifer L. Moran, Steven A. McCarroll, George Kirov, Michael C. O’Donovan, Michael J. Owen. Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia. Neuron, 2015; 86 (5): 1203 DOI: 10.1016/j.neuron.2015.04.022

Sien Braat, R. Frank Kooy. The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders. Neuron, 2015; 86 (5): 1119 DOI: 10.1016/j.neuron.2015.03.042

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Pregnenolone for schizophrenia

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