Pregnenolone reduces negative symtoms in recent onset sz

[SzAdmin]

Good to see the new paper - and the earlier PDF has been discussed before - see the discussions around effectiveness in these posts:

Vitamin Pregnenolone - New Treatment for Schizophrenia - anyone trying it?

Please let me know if you have tried pregnenolone? What effects positive or negative have you noticed? If you haven’t tried it - perhaps try it and report back. I’ve read that it can be helpful in negative symptoms that are common in schizophrenia. The dosing in the top study was 50 mg per day. It can be purchased here (this link is a google shopping search: https://www.google.com/?gws_rd=ssl#q=Pregnenolone&safe=off&tbm=shop I found some clinical trials that had demonstrated effect… Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial. Ritsner MS1, Bawakny H, Kreinin A. Neuroscienc…

and

Pregnenolone - just some more publications

Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: An 8-week, double-blind, randomized add-on two-center trial Pregnenolone for cognition and mood in dual diagnosis patients. Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Just some light reading … if considering supplementing Pregnenolone, make a symptom log. One of its mechanisms modulates GABAa downwards and as such, could…

and

Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-week, randomized, double-blind, placebo-controlled trial

CONCLUSIONS: Pregnenolone with L-Theanine augmentation may offer a new therapeutic strategy for treatment of negative and anxiety symptoms in schizophrenia and schizoaffective disorder. Further studies are warranted. Related DIscussions: and