L-theanine is Effective in Lessening Positive Symptoms, and improving Sleep Quality in patients with schizophrenia

SzAdmin · August 31, 2015, 4:53pm

Everyone who has tried L-Theanine, please respond to the poll we have now on whether its been helpful or note:

insidemind · September 2, 2015, 12:54pm

I finally have some money. Should I buy L-Theanine?

anon32099838 · September 2, 2015, 1:07pm

I took L-Theanine over a year ago for some time, only 150mg(still have the bottle) made me more anxious, so I quit it pretty fast.

insidemind · September 2, 2015, 1:09pm

What about magnesium and COQ10? Any other supplements? What about folate?

insidemind · September 2, 2015, 1:13pm

What ever happened to the drink Tyrodep?

SzAdmin · September 4, 2015, 3:05am

It never seemed to have made it out of testing. I guess the results were not what was expected.

SzAdmin · September 4, 2015, 3:05am

another person’s experience with L-theanine

insidemind · September 4, 2015, 7:56pm

I just ordered l theanine and pregnenolone ( not sure if I spelled it right). I’m kind of worried how it will affect my mood.

far_cry0 · September 6, 2015, 6:21am

u can update on that…

Daze · September 7, 2015, 10:50pm

That sounds like an advertisement.

insidemind · September 8, 2015, 11:12pm

Just took my first dose of l theanine and pregnenolone. Will keep you guys updated.

insidemind · September 9, 2015, 12:05am

Noticed I feel more relaxed but it’s mild. I feel calmer. I think the pregnenolone is causing slight chest pain. I hope it goes away. I’m hoping these drugs improve my negative symptoms, especially intelligence and motivation.

insidemind · September 9, 2015, 1:28am

I’m hoping pregnenolone will cause me to grow a beard. It’s something I really want in life.

insidemind · September 9, 2015, 12:45pm

Is it safe to take 400 mg of l theanine a day? I have 200 mg tablets and can’t take 250 mg.

SzAdmin · September 9, 2015, 4:20pm

The study used 250 mg. I would use 200 mg if you can’t take exactly 250.

I’d keep it at that level for at least a few weeks or longer and see how it goes. Perhaps you have a doctors appointment coming up and can discuss the higher dose with him or her.

insidemind · September 10, 2015, 5:33pm

Third day on L Theanine. I feel more rational, less delusional, smarter, and more relaxed.

insidemind · September 11, 2015, 9:48pm

4th day on L-theanine. I feel more confident and clear-headed. It’s hard to tell what’s from l-theanine and what’s from pregnenolone.

insidemind · September 12, 2015, 5:07pm

How is lysine? Are there any studies of it with schizophrenia? I read one poster is one it.

anon79999497 · September 12, 2015, 5:55pm

ncbi.nlm.nih.gov

Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects.

RF Nasyrova, DV Ivashchenko, MV Ivanov and NG Neznanov, Frontiers in physiology, 2015

Currently, schizophrenia is considered a multifactorial disease. Over the past 50 years, many investigators have considered the role of toxic free radicals in the etiology of schizophrenia. This is an area of active research which is still evolving. Here, we review the recent data and current concepts on the roles of nitric oxide (NO) and related molecules in the pathogenesis of schizophrenia. NO is involved in storage, uptake and release of mediators and neurotransmitters, including glutamate, acetylcholine, noradrenaline, GABA, taurine and glycine. In addition, NO diffuses across cell membranes and activates its own extrasynaptic receptors. Further, NO is involved in peroxidation and reactive oxidative stress. Investigations reveal significant disturbances in NO levels in the brain structures (cerebellum, hypothalamus, hippocampus, striatum) and fluids of subjects with schizophrenia. Given the roles of NO in central nervous system development, these changes may result in neurodevelopmental changes associated with schizophrenia. We describe here the recent literature on NOS gene polymorphisms on schizophrenia, which all point to consistent results. We also discuss how NO may be a new target for the therapy of mental disorders. Currently there have been 2 randomized double-blind placebo-controlled trials of L-lysine as an NOS inhibitor in the CNS.

ncbi.nlm.nih.gov

L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: a double-blind, placebo-controlled, randomized trial.

A Zeinoddini, M Ahadi, M Farokhnia, F Rezaei, M Tabrizi and S Akhondzadeh, Journal of psychiatric research, Dec 2014

Increasing evidence suggest that the nitric oxide signaling system of the brain may contribute to the pathophysiology of schizophrenia, making this system a target for development of novel therapeutics. The objective of this study was to investigate the efficacy and safety of L-lysine as an adjunctive to risperidone in the treatment of patients with chronic schizophrenia during an 8-week trial. Seventy-two chronic schizophrenia inpatients with a Positive and Negative Syndrome Scale (PANSS) total score of ≥ 60 participated in a randomized, double-blind, placebo-controlled trial in the active phase of their disease and underwent 8 weeks of treatment with either L-lysine (6 g/day) or placebo as an adjunctive to risperidone. Patients were evaluated using PANSS and its subscales at baseline and weeks 2, 4, 6 and 8. The primary outcome measure was to evaluate the efficacy of L-lysine in improving schizophrenia symptoms. Repeated measures analysis demonstrated significant effect for time × treatment interaction on the PANSS total (P < 0.001), negative (P < 0.001) and general psychopathology (P < 0.001) subscale scores but not the PANSS positive subscale scores (P = 0.61). The frequency of adverse events (AEs) did not differ significantly between the two treatment groups and no serious AE was observed. The present study demonstrated that l-lysine can be a tolerable and efficacious adjunctive therapy for improving negative and general psychopathology symptoms in chronic schizophrenia. However, the safety and efficacy of higher doses of l-lysine and longer treatment periods still remain unknown.Iranian registry of clinical trials (www.irct.ir): IRCT201202201556N33.

SzAdmin · September 12, 2015, 5:57pm

Here is another related post on the topic of L-Lysine and research behind it for schizophrenia:

Amino Acid - L-Lysine - New Treatment for Schizophrenia - Has it Helped You? DX'd - Other

Please let me know if you have tried this and what your experiences have been with it. You need to take quite a bit of it for it to be effective. If you haven’t tried it - perhaps try it and report back. In this new research study: Each person was taking: 6 grams of L-Lysine every day for four weeks Please try it folks - and report back to the discussion forums after a few weeks of using it. Here is where you can easily it online ($14 per pound / or 454 grams - enough for 2 + months at 6 grams a day): http://www.iherb.com/Now-Foods-L-Lysine-Powder-1-lb-454-g/653# or for more selection - here: https://www.google.com/webhp?sourceid=chrome-instant&ion=1&espv=2&ie=UTF-8#q=L-lysine&safe…

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L-theanine is Effective in Lessening Positive Symptoms, and improving Sleep Quality in patients with schizophrenia

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