Hi Beautiful people, I wanted to create a progress log for my Nootropic stack. I thought might be helpful for me to create a post so as to track my progress as I think it might help keep me accountable. I have been guilty of adding far too many things to my stack in the past and so I wanted to scale it back and start from the ground up.
For background my primary diagnosis is Schizophrenia. I have depression although much of what I experience could just be the negative symptoms. I have recently been diagnosed with ADHD as an adult, make of that what you will. I suspect Iām slightly on the spectrum but nothing to warrant a diagnosis. I have also experienced crippling anxiety in the past, this has all but completely self resolved. While I experienced mixed states during my psychotic episodes, I have also experienced mood elevation without concurrent psychosis, which I likely attribute to the medication. I rarely experience positive symptoms anymore, they appear about once every month or so although my āthinking styleā still has a notably paranoid flavour to it all. My stack focuses mainly on improving cognition and combatting negative symptoms. The dopaminergic drugs that I take have a propensity to cause slight exacerbations in positive symptoms as such my risk tolerance is on the higher end. Since negative symptoms are also likely caused by a dopaminergic pathway itās not a careless approach, moreover, it requires a very fine balance. My schizophrenia is of a paranoid subtype.
Iām scaling back to just the pharmaceutical but I thought however there are still some interesting talking points in my current stack.
Latuda 60mg (night)
Iāve seen some studies that show diminishing returns in response above 80mgs. 40mg didnāt work for me previously. Individual response to antipsychotic medications in particular is SO varied, honestly, you just have to try a few and find what is right for you. Here I opted for something with low weight gain/low sedation. I lost at least 20kg after I switched from the previous antipsychotic. Iām still keen to try brexpiprazole again later down the track. In the short term looking to lower this down to 40mg.
Bupropion 225mg (morning)
Adjunctive antidepressants show some promise. I tried 4 or 5 SSRIs before ending up at this one. For me itās honestly a godsend and I could not recommend it enough. It gives me enough energy to counteract the depression and negative symptoms. Itās an NDRI so maybe itās playing with fire a little but it changed my life. In the past, it has given me hypomania here and there. It never developed into full-blown mania so it was only ever āthe fun bitā and Drs wouldnāt diagnose a mood disorder despite my suggestion. As a result, I have gotten a bit off the leash on this medication before in the past, and all at my prescribed dose of only 300mg. I can confidently say this now but in my experience it often takes a lot longer to nut out the full effects of a medication has when you take it as prescribed which I always do as you will end up vary the dosage very infrequently. I now know this medication has a profound effect on my mood but was also likely the cause of my previous hypomanic state. All in all, it is a favourite medication of mine and like many others, I have tried a fair few.
Ritalin 5mg up to 3x a day (as required)
This is a medication that does what it says it will do, it gives you focus. It doesnāt motivate you in the same way that Bupropion does. This stuff could easily make you psychotic as it has for me when I have stacked the dosage too close to my Bupropion in the past. Works for cognition, maybe less so for negative symptoms. Stimulant medications are powerful and probably not worth it if you experience a lot of positive symptoms. On balance it is an equally powerful tool if you can use it right. Due to the risk of psychosis, this is a hard medication to titrate.
Clonidine 100mg (night)
A surprisingly mild drug prescribed for ADHD I feel it has an anti-anxiolytic effect and is calming in a warm way. By far the most intriguing drug I have ever tried as its effects are quite subtle somewhat like how SSRIs were for me. I feel the effect size in providing focus is really quite small. Due to the small effect size, Iām not sure it warrants long term continuation.
Melatonin 2mg (night)
It works and I feel it has little downside so is worth continuing to take. If you sleep fine already I wouldnāt bother. Some people have opposing views about melatonin but personally, I think there are worse things you could take.
The first thing I will add to my stack is a multivitamin which I will run for 1 month on, 1 month off.
Wishing you luck in your journey, see you then crew.