KarXT and Ulotaront. I heard ulotaront didn’t do that well in testing. What about karXT?
Karxt acts on muscarinic receptors similar to Clozapine, Clozapine also acts on dopamine, GABA, NMDA so its more potent
KarXT has been doing well in the trials so far, it’s looking like it’ll get the greenlight from the FDA
KarXT application made and FDA approval decision expected summer 2024.
Ulotaront phase 3 trials still going with no application yet.
Brilaroxazine first phase 3 results in, good. Application expected mid 2024.
Nice , I’d love to try KarXT
Dunno if it will take longer to come to Canada
Drugs can sometimes take many extra years for Canada approval/insurance coverage.
I figured
Yeah thinks won’t get insured here quickly
But I guess I cannot complain with what I pay since I don’t have any medical benefits at work either
There’s also -
RL-007, cognition, works on cholinergic, gaba b and NMDA receptors
Iclipertin, cognition, NMDA agonist
Evenamide, positive, negative and cognitive, selective voltage-gated sodium channel blocker which modulates glutamate
pimavanserin, negatives, inverse agonist and antagonist activity at serotonin 5-HT2A receptors
brilaroxazine, positive possibly negatives, similar to Abilify
These are all phase 2 or later, there’s dozens more I can’t remember that are preclinical, phase one or phase two
There’s also a lot of investigation going into inflammation as a possible causal mechanism of the disease. There’s a lot of potential here in terms of repurposing and creating new drugs.
Brilaroxazine hit H1?
Ulotaront other trials are ongoing still, karxt has nervous system side effects