What's the latest on the novel mechanism medications?

KarXT and Ulotaront. I heard ulotaront didn’t do that well in testing. What about karXT?

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Karxt acts on muscarinic receptors similar to Clozapine, Clozapine also acts on dopamine, GABA, NMDA so its more potent

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KarXT has been doing well in the trials so far, it’s looking like it’ll get the greenlight from the FDA

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KarXT application made and FDA approval decision expected summer 2024.
Ulotaront phase 3 trials still going with no application yet.
Brilaroxazine first phase 3 results in, good. Application expected mid 2024.

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Nice , I’d love to try KarXT
Dunno if it will take longer to come to Canada

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Drugs can sometimes take many extra years for Canada approval/insurance coverage.

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I figured
Yeah thinks won’t get insured here quickly

But I guess I cannot complain with what I pay since I don’t have any medical benefits at work either

There’s also -

RL-007, cognition, works on cholinergic, gaba b and NMDA receptors

Iclipertin, cognition, NMDA agonist

Evenamide, positive, negative and cognitive, selective voltage-gated sodium channel blocker which modulates glutamate

pimavanserin, negatives, inverse agonist and antagonist activity at serotonin 5-HT2A receptors

brilaroxazine, positive possibly negatives, similar to Abilify

These are all phase 2 or later, there’s dozens more I can’t remember that are preclinical, phase one or phase two

There’s also a lot of investigation going into inflammation as a possible causal mechanism of the disease. There’s a lot of potential here in terms of repurposing and creating new drugs.

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Brilaroxazine hit H1?

Ulotaront other trials are ongoing still, karxt has nervous system side effects