Why is karxt so hyped but I seldom see people talking about ulotaront
I wonder the same.
Because Karxt close to release, that my opinion.
Karxt will be released in 2025, ulotaront in 2026/2027, I think that is the reason.
Both have a mechanism of action linked to dopamine. I suppose that the antipsychotics that will come after these will no longer be linked to this chemical substance, they will be more precise in the neural receptors.
I thought Karxt will be released somewhere in 2024
I asked bing’s chatGPT and it said
According to my search results, Ulotaront and KarXT are two antipsychotic medications that are transforming the schizophrenia, Bipolar and psychosis treatment space. Both medications are expected to be released in late 2024¹. However, the company for KarXT said it hopes to make an NDA application in mid 2023. The application review is about 9 months. So there might be a USA decision in early 2024 for their drug³.
I hope this helps!
Source: Conversation with Bing, 14/06/2023
(1) The newest drugs in the treatment of psychosis: Ulotaront and KarXt. The newest drugs in the treatment of psychosis: Ulotaront and KarXt – schizophrenic blog.
(2) When will KarXT and Ulotaront come out? - Schizophrenia.com. When will KarXT and Ulotaront come out?.
(3) Beyond antipsychotics: a twenty-first century update for … - Nature. Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics | Translational Psychiatry.
(4) Ulotaront - Wikipedia. Ulotaront - Wikipedia.
Thanks for the information
KarXT has 2 phase 3 trials complete with some early results.
Ulotaront has 1 phase 3 complete comparing to quetiapine xr. No results yet for that trial.
Here it says late 2025…
I hope you are right and it’s next year lol
Karuna thinks it will have enough phase 3 trial results this year to file an application.
They will not wait for all trial results.
I am personally more hyped for ulotaront instead of karxt
If KarXT is approved at the beginning of 2024 and not in mid-2024, those of us who do not respond to current antipsychotics would be great news, the happiness it would give me would be enormous. Does anyone know when the KarXT creation process began? that would have to be found out. Since the creation of the molecule is 16 years, it seems to me.
So we could deduce with more precision when it will go on sale.
There has been no NDA application submitted yet and the NDA application takes about 9 months. So we know it is more than 9 months from approval.
Only the company Karuna knows when it will apply. It will not apply until it feels it has the phase 3 trial data needed for approval.