My heart is starting to have problems with abilify, probably by next meeting with my psychiatrist we have to talk about importing newer medicine with less weight gain
Anyone know the targeted launch dates for these medicines?
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I hope KarXT will be launched in the second half of 2024, like it is written:
“The Company remains on track to submit an NDA for KarXT in schizophrenia with the FDA in the third quarter of 2023, with a launch in the second half of 2024, if approved.”
I’m not sure when Ulotaront will be lauched…
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KarXT should be approved 9 months after application. But no application yet. Launch 2nd half 2024 seems reasonable.
Ulotaront lowered PANSS but did not statistically separate from placebo. Caplyta had similar result in a trial. We are not even sure if ulotaront can get approved. IF ulotaront gets approved, it might be 2025 or later. We can only guess. There are still several longer term trials of ulotaront still being conducted.
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Most side effects etc will take some years on human studies no?
But I too remain hopeful that newer meds will be much better for us all
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Wait ulotaront didn’t work much more than placebo? That’s a bummer.
Due to high placebo effect from COVID 19, there’s still a big chance for FDA to approve it like lumateperone
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Hey Robertc, how is Calypta? Did you say it did similar to Ulotorant in the trials? Calypta is an approved drug now, right? Is it very effective and is it a strong AP? I know its supposed to be real good for negatives.Is it very good for positives?
its not untypicical that they publish meds which are failed in one study anyway, if some stuies were successful
Everytime I see “karxt” all I can think of is Mario Kart.
Haven’t looked into these yet, as exciting as new meds are I’m content with abilify.
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Both ulotaront and Caplyta did not separate statistically from placebo in some phase 3 trials. They work differently. Some people thought Caplyta was weak, and some liked it. It helps to have good insurance.
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Ok thanks so much, Robert
There’s another drug in phase III called brilaroxazine. It’s not as novel as KarXT and Ulotaront but it should be easier on the heart.
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Caplyta is a good med for me. It is not a very sedating AP, which I like.
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Don’t think it’s easier on the heart since it targets so many receptors
“ brilaroxazine met all safety endpoints with no weight gain, no increase in blood sugar and lipids, and no cardiac or endocrine adverse effects compared to placebo.”
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Ok nice thanks. How are your positives? When you generally take other AP’s do you usually take the highest dosage/near highest dosage or a low/medium dosage?
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I do not really experience positives. I was on Abilify 30mg and then 20mg. I have a bit of anxiety present on the Caplyta. I’m not sure that it’s a positive symptom cause it feels like normal every day stuff. I was totally out of it on the Abilify. I will take a bit of added anxiety over feeling constantly disconnected and the severe negatives on Abilify.
Just an Update. KARxt was submitted yesterday to the FDA for consideration of approval. Don’t know how long it takes them to approve but I imagine it’s a pretty short process. For anyone interested KARxt is similar in nature to a drug in the phillipines and Asian countries called Areca Nut, Arecoline or Betel Nut as it’s commonly known there. It’s a mild stimulant type drug that is chewed and is similar to Alcohol kinda and tobacco kinda…it works through Muscarinic receptors in the brain by releasing acetycholine in the visual cortex parts of the brain and the VTA. In my opinion it will most likely work like traditional antipsychotics on the market meaning that it won’t be that great for negative symptoms but works ina different mechanism for those that are more “treatment resistant”
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I know that what I’m saying now can cause some debate. But I will not switch to one of the newly approved antipsychotics. First when there price get Down to Maybe a couple of 100 dollars will I reconsider it.
The reason for that is that the public Health Care box is almost empty because 87.000 danish citicents are on a diabetics meds that will keep theme slim even though they are not diabetics, They pay maybe 50 dollars each and the rest off the money is paid by public Health Care.
So my country Cannot afford to supply most of us schizophrenics with expensive antipsychotics.
Not only that, but, we will see more of its side effects with time…