Why are you posting that picture?
To emphasise the importance of DNA
this thread needed a photo to make it more colourful
I can tell you from personal experience that even if alcohol doesnât cause sz it can make it worse.
did I offend you with posting that photo?
no, Iâm not sure why you posted that picture?
just this basically.
because at the end of the day DNA is the recipe book for deciding the design of our bodies and itâs functioning and malfunctioning (including schizophrenia)
âŚI think?
Does agree with this thread with what I typed?
yes
environmental factors including experiences can have an influence on DNA which in turn can wake up the expression of SZ gene/s and you become schizophrenic
I think, IMO
Because i had an issue with a gingercat in my teenage years and started eating marshmallows in my later years. Ah yes, I donât eat brusselsprouts. When i would be sz free noone would have sz. You all got sz cause of me. I am so sorry. I am so punished.
Maybe there is an intelligent schizovirus affecting our brain. Maybe the voices want to learn English.
Your parents could be carriers of inactive sz genes and they get activated in you. Also both or one of your parents could have complementary inactive genes and then when these genes are present in you together they get activated. Ofc depending on gene severity often it takes an environmental trigger like stress, trauma or drugs to activate the full blown disease.
Why were my parents genes inactive?
Is it possible for genes to be inactive?
No one knows how SZ genes are created. Genes can mutate anytime during life or can be present for many family generations.
I too donât have any family history of mental illness or any genetic disorder but I have SZ.
Yes, its possible I learned it in my Cell Biology university class.
Answering genetics questions in one post.
Your parents are likely carriers. The reason why someone becomes a carrier to a pathogenic mutation is because the other gene in the set of chromosome compensates for the mistake in the other chromosome. So the other chromosome makes the coding/protein/enzyme whatever it is, and so the other gene just sit there and do nothing. And thatâs why your parents are healthy. Please see this graph.
Yes. See above.
If you have a heterozygous mutation and if the inheritance is recessive, you are a carrier and this pathogenic mutation can be dormant. A prominent example is my own genetic condition- no one knows why the gene stops working after 20+ years of working somehow okay. Some mutations end up causing defects at birth, but some live a normal life up to oneâs twenties. I lived normally (with a healthy body but with a diseased mind) but my onset came at age 20, with unknown paralysis.
I probably wrote about the pathogenic mutations and inheritance, but no one knows how sz mutations are inherited. It is for sure mendelian inheritance. However, we donât know.
Take central core disease of the RYR1 gene for example: central core disease can be caused by heterozygous (dominant), homozygous (dominant or recessive), or compound heterozygous (recessive) inheritance. Thatâs two different inheritance patterns at once- Iâm not sure why though, but central core disease doesnât say âthis disease has to be inherited in recessive manner ONLYâ.
About this: I assume genes are the same. Since genes do most of the work for us to keep our body going, this may also be why some mutations are developed later in life than congenitally. Just a hypothesis. The reason why genetic diseases develop is because the genes donât do their â â â â â â â job. In my case, the gene doesnât develop its protein because the coding is either stopped or wired incorrectly. After that, the gene stops making its protein and screws up the muscles. This is the same concept for schizophrenia, just different genes.
Also FYI: Thereâs a form of childhood dementia called Battenâs Disease. This disease also affects the brain, eyesight etc instead of how schizophrenia affects the brain with psychosis later in life. Battenâs Disease is also geneticâŚso I guess there are exceptions.
I hope this helps!
(now going back to workâŚ)
I think you are wrongâŚeverybody who is disagreeing with me. Can we debate in a nice way, so we can solve this debate?
There is no way to solve the debate if you just decide from the beginning that youâre right and weâre wrong.
You know nothing of neuroscience, genetics or psychiatry, yet you refuse to believe facts from people who know a thing or two about it.
Thereâs no discussion, just you being stubborn and making an arse out of yourself
I canât convince you if you already have an opinion and if you are not willing to listen.
To be honest, I donât have a degree in genetics but I know a lot about genetics due to having a physical genetic disease. But seriously I canât convince you if you have already decided that youâre right.
I donât understand what is hard to understand.
Is it because you donât trust the science?
I think I trust it out of needing to believe in something and that seems most logical to me