I’m going to start taking it. Hoping it will help with the ‘not doing things’ symptoms. Anyone have experience with wellbutrin?


I was taking two antidepressants along with my abilify, and one of them was wellbutrin. It gave me horrible nightmares. I was eaten alive by a dinosaur in gory fashion every night in my sleep, and it was as though I could feel every bite. I don’t know if it was wellbutrin, or the other antidepressant, or both, or just how they combined with abilify, or what, but after I stopped taking wellbutrin and the other antidepressant, I stopped having such vivid, horrible nightmares.

Yes, I started Wellbutrin over 20 years ago when I was discouraged about wanting to sleep all morning every day (I worked 2nd shift).

It has worked wonderfully for improving my interest in things and my energy level in the morning. I’m still on it. Hope it works for you.

I started the generic for wellbutrin about 2 months ago as an add on 2nd antidepressant. Haven seen much of a difference. Was hoping it would improve my libido too but nothing there yet. But I’ve been having some situational stresses and flashbacks so maybe it is helping as I haven’t spiraled out of control like I normally would have.

I’ve been on Wellbutrin, along with Geodon and Seroquel, for a number of years now. I don’t really notice it unless I stop getting it. Then I miss it.

This all sounds mildly good and uneventful, except for the dinosaur. I could use some dreams of any kind. I’m hoping to can eventually get off of effexor in search of my lost dreams.

Clin Neuropharmacol. 2013 Nov-Dec;36(6):203-15. doi: 10.1097/WNF.0b013e3182a8ea04.
Risks and benefits of bupropion treatment in schizophrenia: a systematic review of the current literature.
Englisch S1, Morgen K, Meyer-Lindenberg A, Zink M.
Author information
Bupropion inhibits the reuptake of norepinephrine and dopamine, which are involved in the pathogenesis of affective, cognitive, and psychomotor impairment in schizophrenia. Because of reports on bupropion-associated psychoses, it is reluctantly used in schizophrenic patients. Risks and benefits, however, have never been comprehensively reviewed.
The objectives of this study were to evaluate the efficacy of bupropion on depression, negative symptoms, cognition, and smoking habits in schizophrenia and to appraise safety aspects.
MEDLINE OVID/PubMed, scholar.google.com and the Cochrane Database were screened for the keywords (“bupropion”/“wellbutrin”/“elontril”/“zyban”) and (“psychosis”/“schizophrenia”/“psychotic disorder”).
A total of 13 randomized controlled trials (28 publications), 3 open prospective evaluations, 5 multiple case reports, 22 single case reports, and 6 review articles were incorporated in the final analysis.
Information on patient population, age, diagnosis, bupropion dose and formulation, antipsychotic and concomitant medication, adverse events and treatment outcomes regarding psychosis, affective and negative symptoms, cognition, and smoking habits were collected from the published reports.
A total of 30 cases of bupropion-induced psychoses have been published, 17 (57%) of which were associated with the immediate-release drug formulation and 28 (93%) of which occurred without concomitant antipsychotic medication. In comparison, 229 schizophrenic patients on stable antipsychotic regimens were successfully treated with bupropion and experienced marked clinical improvement without developing psychosis. Pharmacokinetic interactions with antipsychotics were rare, whereas electroencephalographic abnormalities occurred frequently.
In schizophrenic patients treated with bupropion in addition to antipsychotics, the risk for bupropion-induced psychoses seems negligible. The efficacy of a combined dopamine and norepinephrine agonist in schizophrenia is biologically plausible. Further trials involving bupropion should integrate neurobiological methods and focus on negative symptoms and cognitive deficits in schizophrenia.

Thanks. It’s good to know that a slight chance exists for the drug induced psychosis.

Sounds like it could be promising. I wish I understood all those chemicals. It’s that cognitive deficit…