L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial


•We assessed the safety and efficacy of L-carnosine as an adjuvant to risperidone for treatment of negative symptoms in patients with stable schizophrenia.
•Patients who received L-carnosine showed significant improvement in negative subscale scores of the positive and negative syndrome scale (PANSS) over the course of eight weeks
•Treatment with L-carnosine seems to be well tolerated with no serious adverse events.


Since l-carnosine has shown effectiveness in improvement of cognition in patients with schizophrenia, this 8-week, randomized, double-blind, placebo-controlled pilot study was conducted. Sixty-three patients with chronic schizophrenia, who were clinically stable on a stable dose of risperidone, entered the study. The patients were randomly assigned to l-carnosine (2 gr/day in two divided doses) or placebo for eight weeks. The patients were assessed using the positive and negative syndrome scale (PANSS), extrapyramidal symptom rating scale (ESRS), and Hamilton depression rating scale (HDRS) during the study course. Sixty patients completed the trial. L-carnosine resulted in greater improvement of negative scores as well as total PANSS scores but not positive subscale scores compared to placebo. HDRS scores and its changes did not differ between the two groups. Both groups demonstrated a constant ESRS score during the trial course. Frequency of other side effects was not significantly different between the two groups. In a multiple regression analysis model (controlled for positive, general psychopathology, depressive and extrapyramidal symptoms, as well as other variables), the treatment group significantly predicted changes in primary negative symptoms. In conclusion, l-carnosine add-on therapy can safely and effectively reduce the primary negative symptoms of patients with schizophrenia.

Add-on therapy; L-carnosine; NMDA receptor; Primary negative symptoms; Schizophrenia



Unfortunetly i dont have money for supplement… I am on risperidone btw…!!! @TheBest @DNA…!!! What do u guys think…!!!

Interesting. Thanks.

I’m done experimenting @far_cry0 but thanks for the update, ha.

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What was the outcome Dr dre.!!!

Yeah, that’s interesting !



Try it and update…plz…:om:

I’m thinking about trying 50 capsules.

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@far_cry0 Couldnt sleep, didnt eat, was hard to breathe. just a whole bunch of stuff.

I found that L Theanine in small doses really helps me, so that’s what I’m sticking to.

My cognitive boosters are

Caffeine, L Theanine and Nicotine.

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Here’s another bit of research.

The L-carnosine group performed significantly faster on non-reversal condition trials of the set-shifting test compared with placebo but reversal reaction times and errors were not significantly different between treatments. On the strategic target detection test, the L-carnosine group displayed significantly improved strategic efficiency and made fewer perseverative errors compared with placebo.

The carnosine group reported more adverse events (30%) compared with the placebo group (14%).

  1. I’ve had good experiences with antioxidants 2. I’m on Risperdal 3. I need to increase my speed of thinking. I will for sure probably try this next week.

I got some. I will try it next week.


Make sure to tell us how it goes.

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How are u @Opus…??

Not bad thanks how are you?

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