When I took it I went from 3mg to 4.5mg then 6mg as a last ditch attempt
Didn’t really work, but fingers crossed for others trying it as it’s a newer AP
Now I am on Clozapine and never felt better
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Thats great joker than you are contend and peaceful on Clozapine ( the king of antipsychotics).
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It’s good. Been saying no for years and I regret not just trying it sooner
Still got a few issues at this moment, but that’s more to do with life stress that would sink most people into the ground
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I’m supposed to switch to Vraylar because it’s apparently better for negatives and cognitive function 
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Yes it modulates 5 HT D3 and Alfa 7 a as well 5ht1A. And this mechanism should improve negative and cognitive symptoms to a larger degree than other antipsychotics.
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Let’s hope it’s true
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Each person is different. I feel sedated and have negative symptoms with any current antipsychotic. I think I now understand why there is a high discontinuation rate on these medications.
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I’m on 1.5 and doing okay.
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I’m happy for you. My psychiatrist is more conservative. I talked to him and he told me “we will discuss it another time.” When I asked him to lower the dose.
Mine was happy that I came back to her and admitted I was going downhill and needed to go back on meds.
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Monotherapy?
Do you suffer from any negatives?
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I am not sure what you are asking.
Oh yes. Very much. Vraylar does not deliver in this department like it was advertised.
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Honestly all APs make negative symptoms worse as they all reduce dopamine but the more one blocks dopamine the more in theory the negative symptoms. But I think the biggest chunk of negative symptoms come from sz itself and not only the meds.
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Ugh my pdoc believes it really will help me there
Anyways I guess I’ll try n see
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unfortunately negative behaviors are suppressed but not corrected. This will then be seen as an improvement of negatives…
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does anyone has a tabel with the receptor occupancy of cariprazine. my doc also wants to change my medication. His suggestion is reagila or ziprasidone. But I dont want to take more than 60-70% d2 receptor occupancy. I just found a tabel of ziprasidone. Like this:
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That’s not the only factor in reducing dopamine function, the other important factor is what effect will the med have on the receptor once bound to it, intracellular effects. Antagonists completely block the effects of dopamine while partial agonists like vraylar less so, only partial blockade. Inverse agonists go beyond blocking and reverse the action of that receptor. Dopamine is a full agonist of dopamine receptors. There is also a 3rd factor receptor affinity its how tight the ligand/med bind to the receptor, the stronger the binding the less chance it gets replaced by dopamine.
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This is exactly why I got on haldol vraylar took away all my motivation and I felt dead inside
Haldol I enjoy life again it helps but for alot of people the side effects are too many much and it doesn’t work vraylar is a “safer” med due to side effects of haldol
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i dont know dude. i just reaf about what they call therapheutic window for antipsychotika between 50-70% receptor occupancy. over 70% prolactin increase, akathisia begin, depression and negatives increases. it stands in a scientific work of a german psychiatrist. the receptor occupancy should be the main factor
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