Nice. Any particular one grab your attention?
to me with a rudimentary understanding, it doesn’t look like any of these will be better than the benzos though they may be less addictive. gepirone (i think thats how its spelled) might be like buspirone with more antidepressant effect…
SRX246 sounds interesting.
This blogger also did an article on antipsychotics in 2015. I suppose that means that an update on that will be forthcoming as well.
Hopefully, though he or she tends to write about widely varying topics. Hopefully the blogger will have the time to put something together which accounts for the progression of some of the new meds. Hopefully enough changes have taken place.
Interesting.
"Travivo exerts a stronger effect upon 5-HT1A receptors and minimal interaction with D2 receptors. " Yeah sounds like it may also have some anti psychotic effects with minimal agonism of the D receptors.
Have you ever tried buspirone?
Reading wiki it also sounds good as an AP adjunct …“In addition to binding to serotonin receptors, buspirone is an antagonist of the dopamine D2 receptor with weak affinity.” also interestingly “Some of its effects may be mediated via oxytocin release secondary to 5-HT1A receptor agonism” Ocytocin rocks ! 
Well if it gets through the trials it will be a win for persistence…"The medication was originally synthesized in 1986 and has been rejected
on multiple occasions by the FDA as a treatment for depression. "
It looks good hope it comes through this time.
After reading the list my vote goes to JNJ-42165279! Whoa!!
Its just so intriguing! I love new small molecules with totally novel mode of actions - specially if they have a hint of scandal and media uproar about them.
This one certainly does…
OK so “it functions as a selective inhibitor of the enzyme
known as FAAH (fatty acid amide hydrolase). Inhibition of FAAH enzymes
may generate rapid anxiolytic (anti-anxiety) effects by inducing
long-term depression (LTD) at prefrontal cortex-basolateral amygdala
synapses whereby basolateral amygdala neurons become suppressed”
I think its associated with anandamide an endocannabinoid known as “The bliss molecule” lol … basically the inhibition of FAAH enzymes allow anandamide to not be broken down and do its blissful thing in the brain …
Thats cool if it works
Now the scandal …“another FAAH inhibitor referenced as “BIA (10-2474)” caused severe adverse reactions – including one death. Janssen has stated that trials of JNJ-42165279 were suspended as a precautionary measure.” …Love it ! …only BigPharma comes up these shock and awe stories …It like a sign from the universe that this drug is going to be big :)
Hope the trials start but given its novel approach and association with "The Bliss molecule " . …I reckon there will be more shock and awe media beatups in the offing before its available. Intriguing …
In what way ?
I thought vasopressin was supposed to be agonised - as a nootropic anyway.
Most the anxiolytics listed are neurotransmitter modulators.
I think most of the next generation psychiatric medications will be modulators of the chemicals in our brains.
Hopefully they will be better than the drug cocktails that most of us have to take now to get some relief from our mental health disorders.
Mostly because it’s so far met all its targets and it’s been safe and well tolerated. Less potential for abuse than GABA targeting meds most likely.
Also Xenon is really interesting and unusual.
Always a good sign with anything.
Apologies to @Anon10 for being off-topic a bit …would you (or anyone) have download access to the sodium benzoate study? I was wondering how a preservative came to trialed for sz and thought the citations may hint at the research journey it took…just wondering …
All good with the sodium benzoate research paper - i was entering it wrong in sci-hub…i obviously need more sunlight…
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