Why is there not more talk about CBD? It is currently being tested (phase 2) @Yale and in Germany.
There has been a lot of buzz around this compound yet I can’t find a lot people who have given it a try. Maybe because purified CBD is not readily available (only CBD with thc and other cannabinoids which can have unwanted side-effects even in very low dose).
What should I make of this compound as I am thinking of going in as a phase-2-subject?
Schizophrenia is a chronic disease that manifests through disturbances of perception, thought, cognition, emotion, motivation and motor activity. Over a lifetime, about 1% of the population will develop schizophrenia.
Our product, GWP42003, has shown notable anti-psychotic effects in accepted pre-clinical models of schizophrenia and importantly has also demonstrated the ability to reduce the characteristic movement disorders induced by currently available anti-psychotic agents.
In September 2015, we announced top line results from an exploratory Phase 2a placebo-controlled clinical trial of CBD in 88 patients with schizophrenia who had previously failed to respond adequately to first line anti-psychotic medications. We believe that the signals demonstrated in this trial, together with the safety profile, provide us with the prospect of new and distinct cannabinoid neuropsychiatric product pipeline opportunity, as the mechanism of CBD does not appear to rely on the dopamine D2 receptor augmentation of standard antipsychotics.
We are now analyzing the data to fully understand the appropriate next steps regarding product development in schizophrenia with future research likely focused on pediatric orphan neuropsychiatric indications.
I tried a 40:1 CBD:THC product which I could obtain legally here in California, at the suggested dose I did not notice any effects so I ended up using a huge amount to obtain effects, it was like normal weed but more subdued but I still got really paranoid and detrimental effects so I had to discontinue use. Like you say it is a shame there is not any pure CBD available I would probably give it a try.