Broccoli derivative may prove to be a viable schizophrenia treatment, study finds

News
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More news and the full research paper on this research that was posted about earlier. Please post your results if you are trying the supplement used in this study - Sulporaphane

From the study:

The participants were given 100 μmol sulforaphane as standardized broccoli sprout extract in the form of 2 gel capsules, and instructed to ingest the extract each morning for 1 week.

Patients with contraindications to MRI scanning, such as dependence on benzodiazepine medica- tion, prohibitive claustrophobia, metallic implants or prosthetics, pacemakers, or any medical conditions that would constitute a safety risk to the participant (e.g., middle ear disorder), were also excluded.

Broccoli Sprout Extract (Sulforaphane)

The broccoli sprout extract used in this study is a highly stan- dardized formulation of sulforaphane . The extract was standardized to 100 μmol sulforaphane in the form of 2 gel capsules per day over 7 consecutive days, as described previously. The dose of 100 μmol sulforaphane and the 7-day treat- ment duration were determined empirically from previous studies, including a trial demonstrating induction of antioxidant enzymes in nasal lavage cells of human subjects [59] and improved excre- tion of air pollutants. Our formulation of sulforaphane is 80% bioavailable [58], reaches peak plasma levels 1 h after oral ingestion, declines with first-order kinetics, and is actively excreted in urine (60% at 8 h).

Find the best price for this supplement on google shopping search engine:

https://www.google.com/shopping?nord=1

Broccoli sprout compound may restore brain chemistry imbalance linked to schizophrenia

Full Research Paper below:

sedlak2017.pdf (1.3 MB)

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I’ve ordered some from iherb.com

I’ll just post this interaction too.

Moderate Interaction

Be cautious with this combination

!

  • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with SULFORAPHANE Some medications are changed and broken down by the liver.
    Sulforaphane might decrease how quickly the liver breaks down some medications. Taking sulforaphane along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking sulforaphane talk to your healthcare provider if you take any medications that are changed by the liver.
    Some medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
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Hm. I think I’ll just add more broccoli into my meals for now

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Ugh, I just ordered from iherb, wish I had seen this earlier :woman_facepalming:

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I’m not sure you need to be too concerned about this issue that EverHopeful brings up - here is what they say in the research paper:

As has been reported for cardiovascular and cerebro- vascular diseases, longer treatment duration and/or higher dosages may be warranted. For example, in a clinical trial involving human subjects with type 2 diabetes, improvements in oxidative stress were reported with a dose of sulforaphane of 10 g/day (∼225 μmol) and a duration of 4 weeks, each substantially more than in the present study [80]. This may account for the fact that we only observed suggestive changes in brain metabolites following sulforaphane treatment in the present study. Nevertheless, our short-term dosing strategy was well tolerated, which will further facilitate subsequent sulforaphane protocols in an attempt to link clinical biomarkers with patient-oriented outcomes.

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I’m with you @anon90843118, I will just include more broccoli into my diet.

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Thanks for that @SzAdmin. It appears to be affordable for my situation. I’ll look into it next month. I really do believe broccoli has curative properties. It may make a person gassy but it is one of those foods that has been around since the time of dinosaurs. I grew up in a town that used to grow a lot of broccoli. This supplement highly interests me.

On a humorous side note as a youth people would say, “Now eat your broccoli like a good little dinosaur!”, “Nom nom nom.”

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I’ve bought my supplement. Gonna start on it next week. To be honest, I’m not sure how much we’re expecting to feel from it. I think the main aim is to eventually reduce our meds with it, but we’ll need to wait for the trials to see if there is any success there.

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so how much is in the supplement compared to normal dietary portions?

I really like broccoli so its very cool

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I would like to know too. Unfortunately, I don’t like broccoli :persevere:

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My body can’t seem to process broccoli, so we’ll see how I get on with the supplements!

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it depends how you have it i guess, i wouldnt eat it on its own, has to be cooked as an accompaniment :slight_smile:

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It’s broccoli sprouts that you need. Not sure how much you need if you’re doing it naturally though. You also need to be careful how you cook it from what I have read.

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Yeah, I guess you’re right. I don’t really mind it with chicken. But it has to be with a lotttt of chicken😂

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How is it supposed to be cooked, is it like minimal amount of time?

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That sounds natural enough. Which one should we get? Is this one good?

https://www.swansonvitamins.com/jarrow-formulas-inc-broccomax-30-mg-120-veg-drcaps?SourceCode=INTL4071&DFA=1&UTM_Medium=Shopping&UTM_Source=GOOGLE&UTM_Campaign=SWAN_National_Gen_Shopping_Null_Null_All+Products_Low+4055-01+Immune+Support&UTM_Content=PRODUCT_GROUP&SourceCode=INTL4071&ds_rl=1262629&ds_rl=1263854&gclid=Cj0KCQjwzunmBRDsARIsAGrt4msj_7dUjRCiWDH0oVh67H6hEdxRVcmPfzmeExGF6JoY_HTwodI8aqAaAqB8EALw_wcB

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Something like that I can afford. Hopefully it is suitable TomCat. I’ll likely try that site if it is.

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I don’t know if this video can be trusted or not, but she says 10 mins at 70 degrees celcius.

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According to the description of the supplement i ordered :

Source Naturals Broccoli Sprouts Extract provides 2,000 mcg sulforaphane daily, equivalent to eating more than a pound of fresh broccoli.

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Yeah, there’s no way I’m going to eat a pound of the stuff fresh every day. It’s supplements for me all the way.

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