Anybody take taurine?

everhopeful · April 23, 2018, 8:22pm

I think I’ll give it a go next month. If you take it what’s your experience been ?

ncbi.nlm.nih.gov

Adjunctive Taurine in First-Episode Psychosis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study.

CP O'Donnell, KA Allott, BP Murphy, HP Yuen, TM Proffitt, A Papas, J Moral, T Pham, MK O'Regan, C Phassouliotis, R Simpson and PD McGorry, The Journal of clinical psychiatry, Dec 2016

Taurine is an inhibitory neuromodulatory amino acid in the central nervous system that activates the GABA- and glycine-insensitive chloride channel and inhibits the N-methyl-D-aspartate receptor. It also functions as a neuroprotective agent and has a role in neural development and neurogenesis. The aim of this study was to determine the efficacy of adjunctive taurine in improving symptomatology and cognition among patients with a DSM-IV first-episode psychotic disorder.121 patients with first-episode psychosis, aged 18-25 years, attending early intervention services consented to participate in this randomized, double-blind, placebo-controlled trial conducted from January 2007 to May 2009. Patients taking low-dose antipsychotic medication were randomly assigned to receive once-daily taurine 4 g or placebo for 12 weeks. The coprimary outcomes were change in symptomatology (measured by the Brief Psychiatric Rating Scale [BPRS] total score) and change in cognition (measured by the Measurement and Treatment Research to Improve Cognition in Schizophrenia [MATRICS] Consensus Cognitive Battery composite score) at 12 weeks. Secondary outcomes included tolerability and safety and additional clinical and functioning measures.86 participants (n = 47 taurine; n = 39 placebo) were included in the final analysis. Taurine significantly improved symptomatology measured by the BPRS total score (95% CI, 1.8-8.5; P = .004) and psychotic subscale (95% CI, 0.1-1.5; P = .026) compared to placebo. Additionally, improvements were observed in the Calgary Depression Scale for Schizophrenia (95% CI, 0.1-3.0; P = .047) and Global Assessment of Functioning (95% CI, 0.3-8.8; P = .04) scores. There was no group difference in composite cognitive score (95% CI, -1.7 to 1.0; P = .582). A significant group difference was found on one safety and tolerability item (psychic item 2, asthenia/lassitude/increased fatigability) of the Udvalg for Kliniske Undersogelser, with the taurine group showing a more favorable outcome (P = .006).Adjunctive taurine did not improve cognition, but it appears to improve psychopathology in patients with first-episode psychosis. The use of taurine warrants further investigation in larger randomized studies, particularly early in the course of psychosis.ClinicalTrials.gov identifier: NCT00420823.

anon48059102 · April 23, 2018, 8:23pm

It’s in energy drinks , I drank a lot energy drinks I think it’s bad for your heart. Taurine is stimulant

anon54386108 · April 23, 2018, 8:26pm

I think @DNA does.

everhopeful · April 23, 2018, 8:27pm

I’m not sure taurine is a stimulant

From webmd

Taurine might also improve heart failure because it seems to lower blood pressure and calm the sympathetic nervous system, which is often too active in people with high blood pressure and CHF. The sympathetic nervous system is the part of the nervous system that responds to stress.

anon48059102 · April 23, 2018, 8:31pm

So why there are deaths for people using it too much

Wave · April 23, 2018, 8:31pm

everhopeful · April 23, 2018, 8:32pm

There aren’t

There’s this though :

However, there is one report of brain damage in a body-builder who took about 14 grams of taurine in combination with insulin and anabolic steroids. It is not known if this was due to the taurine or the other drugs taken.

anon48059102 · April 23, 2018, 8:35pm

Might be from coffein

twinklestars · April 23, 2018, 8:56pm

You can overdose fatally on caffeine.

For that matter you can overdose on anything if you try hard enough.

Simonw · April 23, 2018, 9:00pm

This is where Taurine got its name.

DNA · April 23, 2018, 9:09pm

I use Taurine occasionally, it helps with anxiety.

3-5 grams feels like a small dose of benzos.

I megadosed a couple of times with 20g, the only downside was an upset stomach.

It’s a very good amino acid that acts on GABA, I would definetly recommend it. Just start at a dose and work your way up and see how it goes.

It also has a short duration of 4 hours.

everhopeful · April 23, 2018, 9:20pm

That’s good feedback. Thanks.