Lumateperone affects serotonergic, dopaminergic and glutamatergic systems in the central nervous system. It is a potent serotonergic (5-HT2A) antagonist, partial agonist at presynaptic dopamine receptors and antagonist at postsynaptic dopamine receptors.
Latuda also activates 5-HT1A but I still had negative symptoms. I think for me Abilify normalizes dopamine in all the brain instead of fully blocking it, not just in the prefrontal cortex. Its the only thing that worked for my severe negative symptoms.
Ikr, I am looking for a partial agonist other than Abilify/Rexulti that’s available in Canada lol I guess it doesn’t exist. I wish I had a list of all antipsychotics worldwide.