Dopamine partial agonists: a new class of antipsychotic - PubMed


“It should act as a functional antagonist in the mesolimbic dopamine pathway, where excessive dopamine activity is thought to cause positive symptoms, but show functional agonist activity in the mesocortical pathway, where reduced dopamine activity is thought to be associated with negative symptoms and cognitive impairment”

“Aripiprazole produced significant improvements in positive and negative symptoms in short- and long-term studies of patients with schizophrenia or schizoaffective disorder. Improvements occurred rapidly after the start of treatment, and were sustained throughout studies lasting up to 52 weeks. Significantly more patients responded to aripiprazole treatment than to haloperidol in the 52-week study, and aripiprazole-treated patients showed significantly greater improvements in negative and depressive symptoms than those receiving haloperidol”

Partial Dopamine agonists aren’t for me.
Both Abilify and Vraylar made me destabilized.
My anxiety on both meds were unbearable.

I was involuntarily committed on Vraylar.


There are many things which indirectly supports dopamine. These include Vitamin D, C, B1, B12, Zinc etc. Personally I feel vitamin D and B1 most useful. Vitamin C and Zinc useful for reducing anhedonia or lack of pleasure.

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