It is my understanding that all current antipsychotics are either partial agonists or full antagonists of D2 receptors.
Isn’t D4 in the picture too? I’m no expert.
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I sincerely asked artificial intelligence and it told me that. But I wanted to confirm it. XD. Perhaps Caplyta lowers dopamine less than abilify or other antipsychotics.
AI isn’t bulletproof yet. Plenty of experts around but ap’s tend to act on d2 and d4 receptors but maybe that is changed. I’ve no idea of caplyta and it’s interactions. I guess i could use google to confirm?
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They block dopamine I know that
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I didn’t know about d4 receivers, I thought they were just d2 and d3.
I think agonists block or increase D2 receptors, some have more affinity for d3 than d2. A bit confusing really. Almost all interact the same.
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Simple google search.
There are five types of dopamine receptors, which include D1, D2, D3, D4, and D5 . Each receptor has a different function. The function of each dopamine receptor[4]: D1: memory, attention, impulse control, regulation of renal function, locomotion.
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I think what you mean is “partial agonists”. I think its something like this:
Think of the receptors as a door. The partial agonists are supposed to decrease where too much and partially open the door where too little. Something like that. Its been awhile since I studied it.
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dont hold me to it, but I think Caplyta was the one that affected d2 receptors indirectly…but I think the end result might be similar. It still indirectly is a d2 antagonist.
Im not 100% sure. Its confusing stuff.
I might be confusing it with one of the drugs in the works.
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I couldnt find the article that I learned the “door” thing from but here is a pretty good one on partial agonists:
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