I might be in a situation where I get to decide which of these meds I want to try. If you could try one of these medications which one would you pick and why? I feel like even though this is mostly about feeling better myself I’m also doing this so I can give you guys some insight. Maybe some hope. Which one should I try?
Spg302…
Here is why
“We are excited to advance the first clinical therapy capable of reversing synapse loss in schizophrenia, which may provide a much-needed advancement in the treatment of multiple symptoms and patients who are treatment resistant”
What I ment,anything reversing brain damage is far more important
Look at olga_v’s posts on this thread. She’s been on evenamide and the last time I spoke with here she was in remission.
I still think same,but it’s up to you…
I read info on both drugs.
But it’s great thing participating in trials..
Im haven’t decided yet but what worries me about spg-302 is that it’s a regenerative therapy, specifically one that works in the brain meaning if things go wrong I feel like it’s possible they go very wrong. Malformation of nuerons etc.. and I don’t know on anyone who’s been on it for a long time and had to come off it. people have been on evenamide for years and years and it’s moa doesn’t effect the structure of the brain so I feel like there’s a lot less risk involved. It’s also been proven to do amazing things. If evenamide becomes an impossibility I’ll definitely still do spg I’m just chasing evenamide harder.
Ok,evenamide is ok too…
I just read one study from India that was not been done completely relevant..
Yes,I was for spg bc i saw reversing on synapses…
Now I read good things about evenamide.
Besides,I’m on Clozapine and it might be good add on from both meds …
SPG302 without a doubt. The possibility to reverse one of the main mechanism of schizophrenia, which is synapse loss, is just from my point of view exceptional.
Im in communication with someone who’s been on spg-302 for awhile, all of this is anecdotal and just one man’s experience but it’s something. This is what he’s said so far.
I’ve also been in communication with someone who’s been on evenamide. Again anecdotal and just one persons experience but from what they’ve told me they are essentially in remission. It’s unfortunate you can’t find more people talking about there experiences with these compounds but with what I know right now according to anecdotal evidence evenamide is safer, more effective and closer to market.
From my point of view, science is in favor of SPG302. Many recent studies points a loss of synapses in schizophrenics patients, mainly in the prefrontal cortex, cingulate anterior cortex and hippocampus, and in others areas of the brain. If I may ask, how have you been in contact with someone that took SPG302 ? I am on Reddit too, and a person posted months ago on SPG302 for schizophrenia but his profile has been deleted since… I am the man who posted recently about JRT (LSD analog without trip) for schizophrenics on the subreddit schizophrenia.
I agree with that for sure.
You can see the post on Spinogenix website talking about SPG302 for schizophrenia if you haven’t done it yet. It’s very well written. I cannot post links since I am a new user but it’s called “Addressing the unmed need for synaptic regeneration in schizophrenia”.
And neurons are not synapses, schizophrenia doesn’t seem to be a problem with neurons but rather synapses loss. Joseph T Coyle have written a very interesting scientific article in 2024 called “Passing the torch: The ascendance of the glutamatergic synapse in the pathophysiology of schizophrenia”. He estimates arount 35% loss of glutamatergic synapses in schizophrenics.
Most of the evidence supporting spg-302 is pre clinical correct? They proved it can restore glutaminergic synaptic connections in vivo right? That doesn’t say anything about how effective it will be at crossing the BBB or how well it will restore those connections in an actual human brain. The main reason I’m partial to evenamide is because of the data. It’s proven itself in many studies some of which have gone on for as long as a year. Spg is just beginning phase 2 and it just seems to me that the MOA is riskier. I’d prefer a little more data before I try it. I’m not saying I wouldn’t I’m just saying I’d like more data.
Due to the lack of specific safety data for SPG-302, it’s crucial to consider the following:
While SPG-302 aims to promote synapse formation, it’s possible that some side effects could be related to this mechanism. For example, an overstimulation of synapses could potentially lead to changes in brain activity or other neurophysiological effects, as suggested by a news article on practicalneurology.com.
I misspoke there but this post on Reddit leaves me to believe that how spg works is entirely theoretical.
Also you seem a little annoyed, which is weird considering this is a decision I’m making about an experimental substance I’m putting in ME. Kind of weird.
Not at all, I’m not annoyed ! It’s your choice, it’s you that created a topic that says you were going to try SPG302, not me ! If you have doubts about taking it for side effects issues of an experimental drug, don’t take it ! I’m just saying that, in my point of view, SPG302 potential benefits are backed by scientific litterature where multiple studies converge to a loss of synapses in schizophrenics. I saw the positive datas of Evenamide in the clinical trials and it’s a very good thing if it’s working, but I consider SPG302 have much more potential.
I’m going with spg-302. Don’t wanna wait on evenamide.
Hopefully it will work for you ! I have very high hopes for this drug.
None of the actual antipsychotics have en effect on synapses, with maybe the exception of clozapine. Researchers says that maybe the disinhibition of striatal dopamine could be a consequence of synapse loss in the cortex. It would explains also why childhood schizophrenia is relatively rare because there is a net production of synapse when you are a kid that kind of protect the kids to develop schizophrenia, whereas in teenage years there is less new synapses created and the pruning mechanism of synapses begins. Plus, there is a 2024 study that says cannabis use aggravates synapses loss.
