How SPG302 might help

Medications
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Some articles came out yesterday about a new investigational drug SPG302. Apparently it regenerates glutamate neurons throughout the brain. From what I’ve read excessive glutamate is part of the pathology of schizophrenia so It wasn’t clear to me how restoring glutamate neurons might help, unless those new neurons would help with reuptake of glutamate. Any way this is what Bing has to say.

  1. Excessive Glutamate and Schizophrenia: High levels of glutamate in certain brain regions, like the hippocampus, have been linked to the onset of psychosis and other symptoms of schizophrenia12. This overactivity can lead to neurotoxicity and damage to neurons.
  2. Loss of Glutamatergic Synapses: Despite the excessive glutamate, schizophrenia is also characterized by a loss of glutamatergic synapses, particularly in the frontal cortex and other regions34. This loss contributes to cognitive deficits, negative symptoms, and possibly even the positive symptoms of schizophrenia.
  3. SPG302’s Role: SPG302 aims to regenerate these lost glutamatergic synapses34. By restoring the synaptic connections, the treatment could help normalize glutamate signaling. This doesn’t necessarily mean increasing overall glutamate levels but rather improving the efficiency and balance of glutamate neurotransmission.
  4. Balancing Act: The goal is to restore the proper functioning of glutamatergic neurons without exacerbating the problem of excessive glutamate. Properly functioning synapses can help regulate glutamate release and uptake, potentially reducing the harmful effects of glutamate overactivity34.

In essence, SPG302 could help by repairing the underlying synaptic deficits that contribute to the complex pathology of schizophrenia, potentially improving symptoms across the board.

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Phase 2 so somewhile to go yet, however as it is used or ALS already it has more info on safety profiles already.

" SPG302 is indeed in Phase 2 clinical trials for schizophrenia12. While it has shown promise in treating ALS and has received FDA clearance for evaluation in ALS3, this doesn’t necessarily mean it will be released more quickly for schizophrenia.

Each condition requires its own set of rigorous clinical trials to ensure the drug’s safety and efficacy for that specific use. The approval process for schizophrenia will still need to follow the standard regulatory pathways, including successful completion of Phase 2 and Phase 3 trials, before it can be considered for approval12.

However, the existing data from ALS studies might help streamline some aspects of the process, such as understanding the drug’s safety profile3. This could potentially expedite certain phases, but overall, the timeline will depend on the outcomes of the ongoing trials for schizophrenia."

Also, the side effects for ALs patients for this drug are:

"SPG302 is currently being evaluated in clinical trials for ALS, and the reported side effects so far have been generally mild. These include:

  • Nausea
  • Headache
  • Fatigue
  • Dizziness

These side effects were observed during the Phase 1 safety study in healthy participants12. As the trials progress, more data will become available, which will provide a clearer picture of the drug’s safety profile in ALS patients."

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Supposedly it “regenerates” neurons. I wonder if this mean it’s something you don’t necessarily have to take forever.

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Just imagine!

All we ever needed was a short cycle of SPG302 and an injection of an anti-inflammatory found in the new Australian study ( Anti Immflatory Drugs for Schizophrenia - News - Schizophrenia.com

:smiley:

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Thanks for posting @Aimingatremission . I am so down I thought cobenfy was my answer but I probably can’t take it because of my fatty liver and increased liver enzymes. Maybe SPG302 could be my answer but I will be so old when they come out will it really be worth it. :slightly_frowning_face:. At least there are things in the future for the coming generations though. :blush:.

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I think you could take cobenfy if you try slimming down a bit and the medicine will help you slim down further

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Yes I must try to slim down but anytime I try I can’t keep it up :slightly_frowning_face:. I did read that coffee may help lower liver enzymes so will try that as well. Last time I saw a psychiatrist they didn’t want to change my medication. I am going elsewhere next time.

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Sounds like an unreleased Salt, Pepper, Garlic mix.

:herb:

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