Schizophrenia is bundle of 8 diseases not one

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something like this is example where Crispr is used in research for Sz. Once they cure in stem cells they can apply same technology and cure human being who has same genetic defect :https://www.animalfreeresearchuk.org/project/using-crispr-cas9-to-correct-mutations-in-hipsc-from-patients-with-schizophrenia-who-have-mutations-in-dlg2/

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Alzheimerā€™s, Huntingtonā€™s, and Parkinsonā€™s are all fatal, progressive diseases. So thereā€™s a slightly lower bar for tolerable risk.

There are stem cell trials in autism, which is not fatal obviously, but they are mostly cord blood cells.

I also suppose itā€™s possible researchers are afraid a person with sz might not take their anti rejection drugs and become sick.

Anyway I hope it will be sooner, and after all, we wonā€™t know itā€™s gonna happen til one day thereā€™s a report on a human case study.

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Good point. Link I posted above demonstrates protocol: create scenario of sz from particular mutation in dish using Crspr, try treating that first, once you do that try it in humans. Hope they do it successfully soon.

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45

I couldnā€™t load that link, but that sounds like what Lundbeck says they are doing.

Probably a number of pharma companies and university research centers too.

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46

This is more on line of gene therapy than drug discovery though it seems.

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I saw a clip about a mom who helped her son who got run over, his skull hurt, and he already had perhaps bipolar. She never gave up, and there was a lot of publicity, and he got stem cells (from himself), that were put into his spinal column. I wonder if these would work for Schizo. One thought that occurred to me, was that, if there is a damaging process going on that canā€™t be fixed, would stem cells only be a temporary solution?

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48

@Hope345 Thats her:

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Yes, you are right, that is her!

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50

Her son who has indeed BPD and smokes CBD-rich cannabis got intratecal stem cells therapy.

If the problem in sz is pruning, stem cells would only be a temporary solution. Yes.

To be perfectly frank, I dont believe a cure is possible in our lifetime because scientists have no idea what is going on in the brain of a sz.

If we knew, itā€™d be a matter of a few years and some stem cells.

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My opinion is that sz is a first chacra disease. Its a primary chacra and it effects the whole chacra system. How one gets a faulty first chacra. Something to do with sexuality i think.

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Then we need solution through gene therapy and crspr

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guy who cured after bone marrow transplant stayed disease free, and person who got infected stem cells as implant got sz induced so stem cells do something permanent which doesnā€™t seem to go away on its own.

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donā€™t loose hope @GentleSoul, pls check my answer to hope345 below.

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55

Do you have a link? I would like to read about it. So, what I donā€™t
understand is, were they stem cells from the patients own body?

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nope. In both cases they received bonemarrow from donor and hence stem cells with it.

  1. Patient cured:

have not checked this but sounds on similar lines:https://www.psychcongress.com/posters/serendipitous-improvement-schizophrenia-after-triple-bone-marrow-stem-cell-transplant-cancer

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there was link somewhere on forum about patient who received marrow transplant from sibling who happened to be sz patient and developed sz as result.

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here you go:

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this link discusses both cases:https://questioning-answers.blogspot.com/2017/11/can-bone-marrow-transplant-really-affect-psychotic-symptoms.html

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This is call for papers for all who might have survived BMT and have sz:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674517/

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SZ remission after BMT is why i believe stem cells therapy is the cure we are hoping for.

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