Schizophrenia is bundle of 8 diseases not one

I wrote to Lundbeck asking for more info about this the other day, they never sent a reply :(.

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thank you for sharing @twinklestars! my guess so far best bet is 1. gene therapy using Crspr and 2. stem cell therapy both solve problem forever rather than any other drugs. any idea how long these two might take.
I was assuming 5 years.

We dont need crispr. Stem cell therapy is what we need. Id say 20 to 30 years.

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may I ask why are you against CRISPR(easy, human trials going on as we speak,need doing it for sz)? and why in favor of invasive stem cell therapy(need to open your brain,human trials might be 5-7 years)?

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@GentleSoul last post is supposed to reply to your post. Thank you.

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  1. Against crispr: because a. Its not enough. It wont fix the brain. The special neurons that are missing in sz will still be missing. And b. I dont want to alter my dna. And my future kids’ DNA.

  2. Pro-stem cell: a. Its an “easy” way to fix the brain. Repair what is broken. Add what is missing. b. I am sure there will be non-invasive ways to deliver/administer stem cell to the brain. Via the bloodstream. c. There was a show recently with Joe Rogan intrrviewing Mel Gibson and some doctor Neil Riordan (??) about stem cell. The technology just sounds so powerful and non-invasive. Intrathecal mscs stem cell therapy.

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Thank you much for sharing info and thoughts @GentleSoul. Really appreciate that. Just one point, if special neurons are missing due to gene it would be repaired as brain keep regenerating (its the gene that’s preventing certain things from happening,if that’s the cause). That’s what happened in recent Alzheimer’s gene therapy when only one enzyme made all accumulated plaque go away (which takes years to build on as we age).

I shall look for documentary on you tube.I hope some non invasive way for stem cell therapy comes soon!!

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Stem cell therapy

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Wow. you are awesome!! Thanks a bunch!

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If only they could identify the genes involved in mental illnesses. That would be a start. Then workout what activity each gene is responsible for.

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You are right. But can not they start on the ones they already know. will atleast fix part of the population? why wait till finding each gene…

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Didn’t a cancer drug reverse SZ in mice? Just get a stimulated brain going and test a whole bunch of drugs. Going to need a ton of computer power and better understanding of the brain.

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Brain project in US and PRISM project (especially for mental illness) are going to target that. I believe Other project parallel to US BRAIN initiative is about simulating brain. That would take more time I guess time line is 2028 something. I do not want to wait that long.

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Is Prism a chinese project? The chinese are working on a huge genetic sequencing project.

Nope. European one: 1. http://www.sciencemag.org/news/2016/04/european-mental-health-project-targets-biological-roots-social-withdrawal
2. http://www.imi.europa.eu/projects-results/project-factsheets/prism
3.https://prism-project.eu/en/prism-study/ (This one ends in 3/31/2019)

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US Brain Initiative:

  1. https://www.braininitiative.nih.gov/
  2. https://en.wikipedia.org/wiki/BRAIN_Initiative

Europe’s project:

  1. https://www.humanbrainproject.eu/en/

China Brain project:1. https://en.wikipedia.org/wiki/China_Brain_Project

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Remember Human Genome Project was finished successfully before its timeline. Hopefully same for these projects too and hopefully we find cure even before this projects close.

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Excited to notice Prism Project has time line of 2019. Hope that brings end to misery.

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I suspect probably both would be helpful. They’re working on a universal donor stem cell (and they’re using gene editing to do it) so that people who receive donor stem cells would not have to take immuno suppressive drugs to prevent rejection.

I don’t know how far off stem cell trials for sz might be, in part because I don’t know what the protocol is. What’s next, dogs, pigs, monkeys? Is anyone working on that? But I also think it’s much more likely to happen after universal donor stem cells are a thing, and after they figure out less invasive ways of getting the cells where they need to be. Because they wouldn’t want anyone to die from graft vs host disease or surgical complications, particularly from a condition that is generally not fatal.

They are continuing work on gene analysis, powerful computing and artificial intelligence are helping there.

@GentleSoul probably any potential gene therapy for sz would not be on germline cells.

Anyway I would not expect human trials in either for quite a while. Would be nice if it was 5 but probably more like 10-20 years.

But they will trial drugs that act on gene expression in less time than that.

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Thank you for info and nice analysis twinklestars. Please do not forget stem cell human trials are already on for Alzheimer’s as we speak.Same is the case for huntinton’s disease and parkinsons.cure not known stem cell therapy human trials are on. and Crspr in humans are already going on for beta thelesemia in 2018(again no known cure). Why would issues considered above be obstacles only in case of Sz? any ideas?

Thanks in advance,

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