Question about brexpiprazole vs abilify

Medications
1

it says here that

“Rexulti is theoretically a more effective antipsychotic but comes with a larger risk of extrapyramidal symptoms and prolactin elevation, because its intrinsic activity at D2 receptors is 43% vs 61% for Abilify”

Does a lower % d2 receptor occupancy relate to more occupancy? Im confused I thought a lower % equaled lower occupancy…

does anyone know?

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2

That’s confusing for me too. Maybe it’s a bogus article.

3

It sounds like they mixed their numbers up, but I could be wrong.

4

It lets in less D2 than Abilify does. Abilify would reduce the amount of dopamine binding to receptors, Rexulti reduces this amount even more.

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5

Sorry not D2, dopamine. D2 is an inhibitory dopamine receptor