Did anybody try Rixulti?
I’m curious about Rexulti also.
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Why are you changing?
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Rexulti (Brexpiprazole) is similar to Abilify (Aripiprazole). My psychiatrist said they’re in the same family of chemicals and they have similar side effects so he won’t prescribe me Rexulti bcz I had dangerous side effects from Abilify (Many addiction issues and hypersexuality).
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I wonder if there are any differences?
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Better ask a psychiatrist but here’s Wikipedia:
“Brexpiprazole has more blocking and less stimulating activity at the dopamine receptors than its predecessor, aripiprazole, which may decrease its risk for agitation and restlessness. Specifically, where aripiprazole has an intrinsic activity or agonist effect at the D2 receptor of 60%+, brexpiprazole has an intrinsic activity at the same receptor of about 45%. For aripiprazole, this means more dopamine receptor activation at lower doses, with blockade being reached at higher doses, whereas brexpiprazole is the opposite. By contrast, brexpiprazole has a much higher affinity for the 5-HT1A receptor than aripiprazole as well as a much higher intrinsic activity. In vivo characterization of brexpiprazole shows that it may act as a near-full agonist of the 5-HT1A receptor. This may further underlie a lower potential than aripiprazole to cause treatment-emergent, movement-related disorders such as akathisia due to the downstream dopamine release that is triggered by 5-HT1A receptor agonism.”
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It should have lower akathisia risk.
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