Pregnenolone for cognition and mood in dual diagnosis patients.
Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice
Just some light reading … if considering supplementing Pregnenolone, make a symptom log. One of its mechanisms modulates GABAa downwards and as such, could result in heightened anxiety levels. Everyone’s physiology is different and there are so many variables that make our own physiology dynamic in nature too. Worth a read, if nothing else.
Peace
I will definitely try pregnenolone sometime this year. Would be a miracle if it soothed my negatives, if only a little bit.
I had quite a good experience while I was on Zyprexa and Preg (took it for years). With Latuda and Preg quite the opposite, feeling agitated and very tired on it. What’s your guess on this?
Worth a shot - as you can see the studies are quite overwhelming. Ask your GP first (I have to say this) though … numerous APs and SSRIs could be elevating pregnenolone levels already. That being said, if you experience negative side effects, just stopping taking it should pretty quickly stop them and there is no evidence I have seen that suggests lasting damage etc.
You also might want to ask you doc about ways to prevent a subsequent increase in estradiol synthesis (think estrogen). You could drink red wine or eat a bucket load of grapes - which would be my strategy personally lol but the mechanism underpinning that notion is aromatase inhibition.
Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens.
Also from wiki:
Inhibition of aromatase
The inhibition of aromatase can cause hypoestrogenism (low estrogen levels). The following natural elements have been found to have inhibiting effects on aromatase.
Apigenin,[17]Catechin,[18][19]Chalcones,[20]Eriodictyol,[17]Isoliquiritigenin,[17]Mangostin,[17]Myosmine,[21]Nicotine,[22]Resveratrol,[23]Vitamin E,[24]Zinc.[25]
Doing so focuses the pregnenolone down more beneficial pathways. Chart time:
Edit: so I chose a chart that introduces the concept of the pregnenolone steal… now I will have to explain.
In some diseases (such as Cushing’s) and just in the case of chronic stress, cortisol synthesis gains preferential use of prognenolone and is not a good thing at all. Stress is not good, people. Ground-breaking news!
My guess is that the GABAa modulating effects of preg were tipping your neurochemical balance towards excitation.
And if you want to read the full research papers - remember you can always get them (or at least most of them) by typing in the pubmed ID (PMID - see it at the bottom of the pubmed.org summary) into this search engine:
So that second paper - the pubmed ID is: 20493557
And when you type it into the Sci-hub search engine you get the paper (you may need to type in a catcha code to prove you’re not a bot.)
Polymed - by the way - if you just post the Pubmed link into these discussion forums you get the full summary - see below:
If i post this link Pregnenolone for cognition and mood in dual diagnosis patients - PubMed
I get this:
@SzAdmin Thank you for the tips! This type of forum engine is the first of its kind that I have used. I used to be one of those dudes who immediately picked up anything technology oriented … nowadays I feel more like on of those oldies who mutter on about how change is evil. lol
Even though I probably spend more time reading scientific publications than I do lifeing (yes that is now verb), I often get pretty furious trying to find the full article/review etc. and not just the abstract. Though I usually find them eventually … the ones that are free.
Cheers