“Negative symptoms such as blunted affect, alogia, and anhedonia (SANS) were found to be significantly improved with moderate effect sizes among patients who received PREG-LT, in comparison with the placebo group. Add-on PREG-LT also significantly associated with a reduction of anxiety scores such as anxious mood, tension, and cardiovascular symptoms (HAM-A), and elevation of general functioning (GAF). Positive symptoms, antipsychotic agents, concomitant drugs, and illness duration did not associate significantly with effect of PREG-LT augmentation. PREG-LT was well-tolerated. Conclusions: Pregnenolone with L-theanine augmentation may offer a new therapeutic strategy for treatment of negative and anxiety symptoms in schizophrenia and schizoaffective disorder.”
Good find.
The only problem I have is that Pregnenolone is a steroid. I’d be afraid to take it long term.
From webmd (for what it’s worth) :
There isn’t enough information to know if pregnenolone is safe when taken by mouth. It might cause some steroid-like side effects including overstimulation, insomnia, irritability, anger, anxiety, acne, headache, negative mood changes, facial hair growth, hair loss, and irregular heart rhythm.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of pregnenolone during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Pregnenolone is converted by the body to estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t take supplemental pregnenolone.
The stuff sent me insane. I took it about 2 months ago. Never again. Be careful with it as it’s very strong.