Pregnenolone as an adjunct to risperidone for treatment of women with schizophrenia: A randomized double-blind placebo-controlled clinical trial

anon79999497 · July 9, 2017, 12:09pm

Summary: While this trial may suggest a potential effect of pregnenolone on schizophrenia symptoms, further studies are warranted.

ncbi.nlm.nih.gov

Pregnenolone as an adjunct to risperidone for treatment of women with schizophrenia: A randomized double-blind placebo-controlled clinical trial.

L Kashani, N Shams, E Moazen-Zadeh, MA Karkhaneh-Yousefi, G Sadighi, MR Khodaie-Ardakani, F Rezaei, F Rahiminejad and S Akhondzadeh, Journal of psychiatric research, Nov 2017

There have been few studies of pregnenolone therapy in schizophrenia and those that exist have been subject to several critical limitations, thus yielding inconsistent results. We attempted to assess the therapeutic effect of pregnenolone in a patient sample as homogeneous as possible. In this randomized double-blind clinical trial, 82 female inpatients with chronic schizophrenia, who had discontinued their antipsychotic medications for at least one week in case of any oral antipsychotic medication or a month for any depot antipsychotic medication, received risperidone plus either pregnenolone (50 mg/day) or placebo for 8 weeks. Inclusion criteria were acute illness with a baseline Positive and Negative Syndrome Scale (PANSS) negative subscale score of ≥20. Exclusion criteria were the presence of severe depression or other concomitant psychiatric disorders. Primary outcome was defined as the difference in the PANSS total score change from baseline to week 8 in the pregnenolone group compared to the placebo group. No significant difference was found in the PANSS total score changes between the two arms (mean difference (CI 95%) = -9.41 (-20.24 to 1.41); p = 0.087). Significant differences were initially found for PANSS negative change scores (mean difference (CI 95%) = -2.61 (-5.03 to -0.19); p = 0.035) and general psychopathology change scores (mean difference (CI 95%) = -5.93 (-11.37 to -0.48); p = 0.033). However, these findings did not survive Bonferroni correction for multiple testing. While this trial may suggest a potential effect of pregnenolone on schizophrenia symptoms, further studies are warranted.

Full Research Paper Available for Download Here:

http://sci-hub.cc/10.1016/j.jpsychires.2017.06.011

frencheese · July 9, 2017, 2:37pm

There was another study that said that pregnenolone worked for men and not women, so now I think Im taking it for no reason.

twinklestars · July 9, 2017, 3:41pm

If you go off it, tell us if you think anything changes for you?

far_cry0 · July 9, 2017, 3:43pm

U both ladies can try it …thanks…

twinklestars · July 9, 2017, 3:44pm

The study, and one other, suggests it’s not effective for women, but may be for men.

far_cry0 · July 9, 2017, 3:45pm

I dont have money tho sorry…haahahah.!!!

NutsAboutU · July 10, 2017, 1:11pm

50mg pregnenolone daily gave me aggressive thoughts. It’s powerful stuff so be careful…

frencheese · July 12, 2017, 2:56am

I may go off of it. If I do I will post an update.

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Pregnenolone as an adjunct to risperidone for treatment of women with schizophrenia: A randomized double-blind placebo-controlled clinical trial

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