I already posted this in the Pregnenolone thread but that one is too crowded with some off-topic stuff.
I just want this to get more attention and have it’s own thread. If I’m doing it wron remove it. Who knows maybe some docs would see this and do (more) studies!!
"Ok lets do some link copypasta!
Are you familiar with the NMDA-Hypothesis of Schizophrenia? read Here NMDA receptor and schizophrenia: a brief history. It says that there is a NMDA receptor HYPOfunction in SZ (note, HYPO, Thas also why the NMDA-Antagonist PCP (angle’s dust) causes Schizophrenia.). And Preg (sulfide) fixes that. “Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate (NMDA) receptor” it somehow activates NMDA.
The other thing is that Pregnenolone is a “negative allosteric modulator of the GABAA receptors.” It makes them underactive. GABA agonists are Benzos (volume, xanax) and such so Pregnenolone, which does the opposite. would make you theoretically restless. But there is a good side to it. A VERY good side. Deactivating (of sorts) of GABA-A receptors by Pregnenolone increases Neurogenesis (birth of new neurons) in hippocampus. Link to study. Schizophrenics has been found to have small hippocampuses. Theoretically your Hippocampus should grow.
Pregnenolone also does the opposite of THC (Marihuana) it is a cannabiloid type-1 (CB1) receptor ANTAgoinist, while THC is a CB1 AGOnist. If MJ is bad for Schizophrenia I suppose it’s opposite could be good for it! (wild speculation)
Pregnenolone can protect the brain from cannabis intoxication.
It sounds all very good to me. But I don’t care about the theory that much. It’s just totally helping me. A very interesting “side effect” is that I now understand what Eckhard Tolle was talking about all the time…"
