Medical Marijuana(Cannabidol),A chance for Revitalize of The lost myelin.
Multiple sclerosis,a progressive chronic nervous disorder related to central nervous system,is the prominent disability of young adults.Demyelination in central nervous system is the characteristic of main pathologic in multiple sclerosis which counts as prior inflation process and its repetition results to neurological disorders.Despite the fact that the main reason for Demyelinating is unknown but it seems alteration in different genes and interference of environmental factors could have some roles in creating this disease.One of the present treatments for MS includes strategies for missed myelin restoration.Through this to support olygodendrocytes and stimulate OPCs(oligodendrocyte progenitor cells) for remyelination some factors are splashing naturally from astrocytes such as neurotrophins and Insulin like growh factors.One of compositions for the treatment of this Demyelinating diseases in increasing supportive factors which can be useful in Remyelination,is cannabis Sativa known as Marijuana.It can be extracted about sixty composition through this plant such as Tehtrahydrocannabinol(THC 9),the most important one,(Cannabidiol(CBD,) Tetrahydrocannabivarian(THCV,)Cannabichromene(CBC.Cannabidiol is Epileptics,Relax makers of the muscles,anti-anxiety,Antioxidants and supports neurons and lack of psychoactive characteristics and also because of its ability in regulating immune system and decreasing of THC side effects,it is considered in medicine.Different cells of CNS such as neurons,Astrocytes,olygodendrocytes and micro glias,CB1 And CB2 receptors,which is considered natural receptors of the body against Cannabinoid,explain themselves.On the other hand astrocytes are affluent cells of glial cells in CNS which their defective functions can produce diseases such as Neurodegenerative and Neuro-Inflammatory ones.It seems cannabidiol can be after attaching to their receptors increases nuero protective factors such as Insulin like growh factors and neurotrophins,stimulating the proliferation and differentiation of olygodendrocytes and have important roles in myelin restoration and movement improvements in patients.