Currently, Prof. Falkai’s team is conducting a new randomized controlled trial combining aerobic exercise with Clemastine, a repurposed drug, to enhance myelin regeneration and improve cognition in schizophrenia patients. This innovative approach could revolutionize treatment strategies, particularly in the early phases of the illness.
Here is an article that says that cannabis impairs development of the brain and interrupts the CB1 gene which impacts plasticity of the brain, so if you combine this research with the OP then the future lies here.
Cannabis Impacts Brain Plasticity via Astrocyte Receptors - Neuroscience News
"Researchers discovered that cannabis affects brain development by interacting with CB1 receptors on astrocytes, not just neurons. Using a mouse model, they showed that removing these receptors impaired the brain’s ability to adapt during critical periods of plasticity, particularly in the visual cortex.
This highlights how astrocytes, often seen as supportive cells, play a direct role in early brain flexibility. The findings suggest that disrupting CB1 receptor activity during development, such as through cannabis use, may have long-term impacts on learning and brain function."
Also I thought Columbo died awhile ago…
And then he pops up in a laboratory
Just one more question !
From the Wikipedia article about Clemastine:
Clemastine has been studied for its potential to treat several psychiatric and neurological disorders, including possibly promoting remyelination and myelin repair in conditions like multiple sclerosis (MS).[13][14] Early phase II clinical trials showed promise for promoting remyelination in patients with MS, with clemastine improving nerve conduction velocity in the optic nerve.[15][16] However, a clinical trial (TRAP-MS) was halted in early 2024 after researchers found the disability progression was occurring at a significantly faster rate than anticipated in three participants with MS receiving clemastine.[17][18][19]
which shows over well over 90% of studies are incorrect, misleading, unnecessary etc
AI Overview
Psychotic reactions can be a side effect of clemastine, a histamine blocker. These reactions can include hallucinations, confusion, agitation, anxiety, and paranoia.
Explanation
- Clemastine can cause serious side effects, including mental and mood changes.
- Overdosing on clemastine can cause paradoxical symptoms, including stimulation and CNS depression.
- In children, stimulation from an overdose can lead to excitement, hallucinations, and loss of coordination.
- In adults, an overdose usually causes CNS depression, ranging from drowsiness to coma.
- Clemastine can interact with other medications, including those for depression, anxiety, and psychotic disturbances.
Other side effects of clemastine Ringing in the ears, Trouble urinating, Easy bruising or bleeding, Fast or irregular heartbeat, and Seizure.
Therapeutic potential
Columbo would be proud.