Which meds are the strongest? Which are the weakest?
I am mostly interested in ablify and vraylar.
Are they considered strong or weak as AP’s?
And also I am interested in others. Olanzapine as I know is truly effective, but in my case it was very unhelpful and made me a zombie.
Also, quetiapine and haloperidol? I took these two long time ago.
Maybe someone could make a list of most popular Ap’s by strength?
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This is complex
AI wouldn’t touch it
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I think it’s more about how your body processes the drug rather than it being stronger or not
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I’ve always thought that Abilify was a weaker AP but it’s a lot more potent than I thought
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Bring me Coffee I can tell you that Clozapine is considered the most efficious antipsychotics of the atypically and illoperidone is considered the weakest.
I think that Vraylar is considered stronger for positive symptoms than Latuda.
But the statistic on antipsychotics on efficiency and the probability for causing side effects tells nothing about how a specific meds works for you.
They are just statistics.
Now if a sudden neuroleptics clears your psychosis 75 % or more and is not causing any bothersome side effects then you are considered as Super Responder.
So go for Super Responce by trial and Error.
And if two neuroleptics at the same time do that.
Then go for two Antipsychotics.
I am super responder on two antipsychotics but it really took decades to arrive to that place.
So never touch a running system if you want to keep Super Responce.
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So I believe vraylar could be considered somewhere in the middle as AP? (By strength)
in my journey strong AP such as olanzapine had zero effect on me. It actually even made me worse, I gained weight, was super silent and without any facial expression.
Though haloperidol was quite effective. I remember on haloperidol I started seeing first improvement about my psychosis.
in my journey ablify helped me the most, it made me stand on my foot.
Now on vraylar I have 0 symptoms, but I feel like (my pdoc feels the same) that in years, maybe 2 or 3 I could stop meds.
So yeah probably it depends on how person is affected by med. Because from what I see here on the forum, every person needs a different med. That’s why there are so many meds @Ghosts
I think most meds act by numbing sedating one’s mind
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Most effective is Clozapine. Then Amisulpride. Vraylar and Abilify are somewhere in the middle.
However, Abilify is the strongest medication for me. Voices were wiped out on only one medication after I tried maybe 10-15, and that was Abilify. It simply wiped the voices out.
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Amisulpride is by far the best medication in terms of cost-benefit analysis. It has one of the least weight gains, while it is almost as effective as Clozapine.
However, it has one drawback, and that is high prolactin. Fortunately, the other medication I take is Abilify, which lowers it such that I have a reasonable sex drive.
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I had my worst psychotic break while on vraylar; it didn’t do anything. I can’t go on just one antipsychotic, as I’m on three right now. Haldol at 40mg is pretty strong for me, but it also caused Parkinson’s symptoms at 20 years old, so I don’t know if I’d recommend it. However, each medication reacts differently for different people.
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Clozapine then amisulpride are the most efficacious.
I love amiulpride even though my prolactin is elevated.
So effective.
My gonads are dead though 
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The med’s can act differently on people who are using med’s to help them function better in life. Generally speaking the “typical” antipsychotics are stronger than the “atypical” antipsychotics. That’s the only major difference between med’s that I know.
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Clozapine, amulsipride, Risperdal, Zyprexa are strong. Abilify, Seroquel and many others considered less potent for most.
This article, after several pages, has a potency chart. (Figure 4.)
https://www.thelancet.com/article/S0140-6736(19)31135-3/fulltext
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John if I remember right you are on the antipsychotics. Haldol , Calypta and Ziprasidone.
How are your psychosis now ?
And does the Calypta do its job regarding the negative symptoms and cognition.
Lastly I’ll just say that most of my life I’ve been on two antipsychotics at the same time.
I was even on 3 antipsychotics at the same time for 10 years. Namely the meds Clopixol LAI, Ziprasidone and Seroquel.
Now I’m on only two antipsychotics. Clopixol LAI 500 mg every 3 weeks and 700 mg Seroquel by mouth. (Had to upper to 700 yesterday because of mood swings).
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That is correct; those are the three that I am on. And my psychosis is a lot better than a few weeks ago. It was so bad that my dad stayed up with me one whole night to make sure I didn’t do anything dumb.
However, as far as my negative symptoms and cognitive impairments go, I’d say that caplyta does help most definitely with my negative symptoms, but cognitive symptoms are hard to tell because I’m trying to get past my ADD.
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You are really a fighter and so brave. Thank you for your recommendations of Calypta for negative symptoms.
Best wishes from your fellow suffer N.
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Thank you, I think you’re also a great fighter and focused on getting better. I commend you for that.
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You’ve got a good dad. I would have loved to have someone sit up with me sometimes. I’m doing better these days. I’ve made calls though in the middle of the night in the past.
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Thank you, I do have a great support system.
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I’ve tried a lot of the newer antipsychotics and the ones the worked seemed to handle the symptoms very similarly. Then about two years ago I tried my first typical one, perphenazine, and the voices went away as well as the severe thought broadcasting and ideas of reference. The side effects aren’t as bad either. Different people react differently but I found invega and zyprexa to be pretty strong compared to seroquel, abilify, and geodon. Those three made me crazy. I think the trial and error works the best. I was lucky to find perphenazine. I had no idea I wouldn’t have positive symptoms all the time. I’m never zombified though. I seem to run tense and alert most the time. I see some people at day treatment that seem to slow down on them. I slow down but I’m not slow. I wish I could relax more.
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