Looking for a sleep drug

Medications
1

I am looking for a sleep drug (against insomnia) with the following properties:

  1. It doesn’t make one addicted.
  2. It has low affinity to dopamine receptors.

I tried Mirtazapine, but I have serious adverse effects even with 3,75 mg.

What about:

  1. Doxylamine
  2. Promethazine
  3. Trazodone
  4. ???
    ?
2 Likes
2

and:
3. It should not have many (serious) adverse effects.

3

Wutang here just houghtbi would say hi

4

Go for seroquel…

5

Diphenhydramine and Doxylamine are good choices due to their length of action and can be bought without a prescription.

6

I take Trazadone for sleep. I have to up the dose a little bit more and hopefully it doesn’t stop working. I started with 25mg and now I’m up to 150mg. I don’t feel any grogginess or any other side effects so far.

7

Thanks.

Seroquel has too high affinity for dopamine receptors.

I fear the adverse effects of Diphenhydramine, but Doxylamine and Tazodone look interesting.

8

what are the adverse effects of diphenhydramine?

9
1 Like
10

Thank you for that but those are basically the same side effects as doxylamine and trazadone too aren’t they? Is diphenhydramine worse or something?

11

400mg of 5-htp followed by 2mgs melatonin half a hour before bed

12

Try Promethazine. That’s what i usually take to get a good night’s sleep. It is an antihistamine that is sedating. It shouldn’t react with dopamine, and there aren’t many side effects that i know of. I’m sure there are some but i’ve not experienced any.

13

I took zopiclone for years and it was crazy. I’d sleep but did weird stuff in my sleep. And i had way funky dreams. I wouldn’t recommend it to anyone

14

I take 300 mg of trazadone and I sleep soundly…only that dose works for me with trazadone.

15

At the moment, I am also most interested in Promethazine. How much do you take?

16

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If Diphenhydramine only had lower affinity to M1-5, it would be perfect!

1 Like
17

Trazodone is good.

18

I take 25 mg tablet. That does the trick for me. The first time you take it, it may make you a little drowsy the next day…but then again, we take AP’s so we’re probably immune to that effect.

19

I take 100-150mg of Trazodone and it helps keep me asleep and avoids fitful dreams

20

@anon9805972, I take Melatonin 6 mg three hours before bedtime. This really seems to help the majority of the time. Sometimes, I take Magnesium Carbonate fizz powder in water before bed. This also seems to help. I do yoga for a half hour, two hours before bed, (this seems to relax me). I also take Klonipin 0.5 mg if I am still awake at 1 am in the morning. With all these regimens, I sleep soundly like 98% of the time. And I have sza, which is notorious for sleep problems.