Im going to try an unproven new drug

I’m going to try REXULTI, probably in a few months. I’m desperate. Would you or have you ever tried a drug soon after it came out?

It’s abilify made over.

1 Like

It’s supposed to be more tolerable. I’m on abilify, it’s impossible for me to tolerate any more.

It might be. But the price is way less tolerable.

@samples32 is right, btw.

1 Like

@notmoses, Would you try it just after it came out, if for example it promised to get rid of your voices? How brave would you be with their tweaking?

I see Rexulti as a comparison to Invega > Risperdal.

1 Like

I’m not sure, but i think Latuda is a new drug too. When i went to the hospital they gave it to me. So it depends on your doctor and if they want to try certain drugs on you.

Just listen to your doc and let him choose the meds, he knows best.

1 Like

Out since 2010…

I went on Abilify soon after it first came out - like I said before, if Rexulti is going to have less Akathisia, then it would be worth the switch.

My doctor is going to keep an eye on how well it does - I may still get a chance to try it - I don’t know yet

The ability to arrange to switch to a new/different med seems to be very much a US thing. Here in the UK we get put on a med and if the med doesn’t work, or stops working, it’s the pdoc who decides what alternative med we get put on.

It’ll be that way here once “evidence-based,” algorithmically locked down, socialized medicine practiced in the UK really grabs hold here. We’re about a decade behind you. I am NOT looking forward to this, personally or otherwise.

I think it has as much to do with pdoc attitudes as socialised v non socialised medication.
There is always talk about privatisation increasing consumer choice but in a “pay to be treated” system how true is this really? Availability/acess to choice of treatment is inevitably governed by available personal income in a privatised system.
For me this is ethically/morally wrong. Availability of treatment should be governed by clinical need not the size of one’s income .

I agree, but the opposite is exactly what we have been seeing here as the HMO model has taken preeminence for the masses, while the PPO model continues for the better off, and the pay-for-the-best model remains for those with the means to use it.

Just do your homework , and readup on the clinical studies.

1 Like

Clinical studies only lasted for 6 weeks. Ideally I’d wait a year to make sure there was nothing obviously wrong with the drug. I keep flip flopping between wanting/needing to try it immediately and common sense telling me to wait a year somehow.

If its Fda approved , it lasted anything up to 4-5 years

I’m not sure of FDA processes but hardly 6 weeks ever hopefull. What’s the med for, is it a new novel AP drug or is it a reformulation of something else?

The approval process took 4 years probably. The trials themselves only lasted 6 weeks each. It’s a reformulation, not brand spanking new.

The below is from wikipedia.

Phase I Edit
Trial to Evaluate the Effects of OPC-34712 (brexpiprazole) on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder[14]
Phase II Edit
A Dose-finding Trial of OPC-34712 in Patients With Schizophrenia[15]
Phase III Edit
Efficacy Study of OPC-34712 in Adults With Acute Schizophrenia (BEACON)[16]
Safety and Tolerability Study of Oral OPC-34712 as Maintenance Treatment in Adults With Schizophrenia (ZENITH)[17]
Study of the Effectiveness of Three Different Doses of OPC-34712 in the Treatment of Adults With Acute Schizophrenia (VECTOR)[18]
A Long-term Trial of OPC-34712 in Patients With Schizophrenia[19]

The references are the end of the Wikipedia Page. You’ve probably done this your self. I’ll post the link