Glycine versus Sarcosine


#21

Like sarcosine turns into glycine , beta alanine turns into L-carnosine. L-carnosine has research behind it to say that it helps with negative symptoms .

L-carnosine didn’t work out for me so I’ve just ordered beta alanine to see if that works. I’ll report back.


#22

Have you tried Sarcosine then? So Sarcosine is like a methylated form of Glycine in that it crosses the blood brain barrier? Kinda like methamphetamine is a methylated form of the amphetamine varieties (dextroamphetamine, levoamphetamine, etc.). Is that what Sarcosine is?

Any opinions on DMG (dimethylglycine)?

Here’s some info about Glycine though:

NOW Supplements Glycine 1000 mg

“Glycine is the smallest and simplest amino acid, making it versatile for use in a wide range of functions. Glycine is necessary for the production of glutathione, DNA, creatine, bile, hemoglobin, and most proteins. It also helps to promote glycogen storage, thereby making glucose readily available for energy production. Glycine also functions as a calming neurotransmitter in the brain, where it facilitates nerve impulses and is important for the maintenance of healthy sleep patterns.”


#23

I tried glycine and it didn’t do anything for me it just made me feel sick/nauceous. I don’t want to try sarcosine as there’s a (weak) link to cancer.


#24

I see. Do you have schizophrenia?


#25

Yes! Paranoid schizophrenia.


#26

I can tell by the fear of getting cancer (possibly). I don’t have schizophrenia but I’ve looked into various treatments of various psychiatric illnesses. Have you tried the antibiotic Minocycline?


#27

You should be on the family forum then!

The @moderators can give you more info if you need it.


#28

I think Sarcosine is more potent than Glycine alone.


#29

I got the info from this link regarding glcyine being used at 60 mg, not gram!

https://www.medscape.org/viewarticle/778119_6

“In contrast to other glutamatergic drugs, glycine acts as a coagonist at the NMDA receptor site and hence increases glutamate transmission. In a double-blind RCT, patients on glycine at 60 mg/day showed nonsignificant improvement in OCD symptoms, but it was associated with poor tolerability due to unpleasant taste and nausea.[90]”

So in other words, the improvement was “there” just not significant enough due to poor tolerability? I have used glycine before 1000 mg 1-3 times daily. I think it was OK in my opinion. I have yet to try the most talked about Sarcosine to make a comparison though.