I recently read up on this amino acid and was surprised to see it could improve negative symptoms with as much as 24-49% in different human trials. I decided to try it, and it does seem to help me noticably.
“Later, glycine was demonstrated to improve negative symptoms at 0.4 g/kg/day (81). Consistently, recent clinical studies have also indicated that a high dose of glycine is associated with improvement in clinical rating scales of schizophrenia, especially scales of negative symptoms (70, 71, 82, 83, 86, 89, 90).”
The article suggests 0.4g per kilogram weight which is a very high dose. I’m getting positive results even at 9 grams daily, which is 0.1g per kilogram in my case. It will be interesting to see if glycine has a long term effect.
Note that glycine is contraindicated if you take clozapine, as it seems to make the drug work less effective.
That is interesting because recently we have a post on SPG302 that repairs the neurons in the brain that are related to glutamate and glycine intake and uptake.
It is thought that szs suffer from excess and lack of these things in the brain.
So on one hand it could be helping you and on the other too much could also be bad for you.
some of the foods I eat contain Glycine
Canned salmon (1.4 g per 100 g)
Peanuts (1.6 g per 100 g
Red meat: (1.5 to 2 g per 100 g serving)
Eggs: ( 0.40) whole egg
I tried it, apparently you must take a massive dose for it to work as it does not cross the blood-brain barrier, around 40 grams per day, if you try this you might throw up, I did and I did throw up! There is another supplement that has the same effect (an NMDA agonist) called sarcosine, you are better off just taking that. Sarcosine helps me alot with my negatives and some on my positives, works like a charm, no side effects, not a thing! You can order it on Amazon, it is about 2 years out from being available via prescription but can be ordered online right now!
Different things work for different people. I get a improvement in negatives just taking 1 teaspoon(3-4 grams) of glycine. Sarcosine gave me massive headaches, could not use it.
I wonder if how effective glycine and sarcosine are for you is any indicator of how well you’ll do on iclepertin. Iclepertin basically does for glycine what ssris do for serotonin.