Ever heard of MTHFR gene. It's a disease that you cannot absorb B-vitamins properly

Basically if you have a mthfr mutation gene you cannot absorb folic acid and you have to take methylfolate (the form of folate easily absorbed) to get your folate levels up.

You can get tested for this gene for £180 in the uk. The results can take anywhere up to 8-10 weeks. It’s a simple saliva test, they send you a swob and a small tube and you simply swob your mouth then send it back to the company.

I’m gonna get tested. They also test all your DNA from calcium channels to all vitamins and minerals to see if anythings wrong.

If you have mthfr mutation gene, you can get it fixed by using methylfolate.

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Here’s the MTHFR site to get tested. It’s something like 50% of the population has this mutation gene.

http://www.mthfr-genetics.co.uk/

I have an mthfr mutation. It was the cause of severe spina bifida in one of my pregnancies that eventually led to miscarriage.

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@LED.

Do you take methylfolate for it? And how much do you take?

I heard it can take 6 months to a year to get back folate levels.

I’m very sorry about your miscarriage too.

Jeeze that is a lot of money for a test! I think for such things at least should be subsidised so the consumer doesn’t wear all the cost! I know it’s not cheap to do labwork but that is a no brainer there should be some assistance!

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Yes, I have the mutation but don’t take anything for it. In fact, it wasn’t until I read your post that I logged into my 23andme account to see if I have it. The gene is MTHFR C677T – SNP: rs1801133 with a genotype of AA. I purchased my DNA test thru 23andme for $199. Worth every penny in my opinion as it explained why I suffer with so many conditions.

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@rogueone, @Persia

Yes that’s what I thought, I thought it’s quite expensive, but what they check is everything.
It’s quite astonishing. I guess if you done the test it’ll save you money in the long run.

That’s good news Persia, at least now you have something to go on. Maybe you should start supplementing with methylfolate. It’s up to you.

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I don’t want to be insensitive towards anyone’s stuggle but I’m not going to lie, I totally thought MTHFR was an acronym for ■■■■■■■■■■■■. :sweat_smile: :joy:

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How are u @valiumprincess … What are u upto…!!! I am about to wake up…its 2.26pm here in nepal… go get some sleep …!!! Anyways take care…!!!

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Hi @far_cry0 I am doing well, it is snowing lots here right now, it’s 1:35 AM where I am. I had a few coffees so I’ll probably have some trouble sleeping, I don’t mind though :slight_smile:

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My folate- geneticoncept site

Folic acid - Wegene site

https://www.snpedia.com/index.php/Rs1801131

CC= Number of risks. Complex.

Again from geneticoncept

Vitamin B6

Vitamin B6, also called pyridoxine, helps your body`s neurological system to function properly, promotes red blood cell health, and is involved in sugar metabolism. Vitamin B6 is found naturally in many foods, including beans, whole grains, meat, eggs and fish. Most people receive sufficient amounts of vitamin B6 from a healthy diet, and B6 deficiency is rare in the United States

The genetic marker rs4654748 in the NBPF3 gene (near the ALPL gene) has been found in multiple studies to be associated with reduced levels of vitamin B6, possibly due to faster than normal clearance of this vitamin from the bloodstream. Individuals with a C/C or C/T genotype had lower levels of B6 than those with the T/T genotype. Therefore, if your genotype is C/C or C/T, you will get a result of “Optimize Intake.” If your genotype is T/T, it is suggested that you “Stay Balanced” and maintain a healthy diet. The studies we report observed associations between vitamin levels and particular genotypes; however, that does not mean that your levels are out of balance. You should ensure that you are eating a healthy diet and discuss this result with your physician.

YOUR RESULTS
Gene Your results Effects
NBPF3 CC Lower levels of B6

Conclusion : Optimize your intake. People with your genotype are more likely to have lower blood levels of vitamin B6. You may optimize your intake of vitamin B6 by paying attention to your diet and eating foods rich in vitamin B6.

Vitamin B12

Vitamin B12 plays an important role in how your brain and nervous system function. It helps to keep red blood cells healthy and is a critical component for synthesis and regulation of your DNA. Vitamin B12 is found naturally in foods of animal origin including meat, fish, poultry, eggs and milk products. A healthy diet will typically provide sufficient B12, although vegetarians, vegans, older people, and those with problems absorbing B12 due to digestive system disorders may be deficient. Symptoms of vitamin B12 deficiency can vary, but may include fatigue, weakness, bloating, or numbness and tingling in the hands and feet.

Multiple genetic studies have identified a marker in the gene FUT2 as being associated with lower levels of B12 in the blood. This effect may be due to reduced absorption of B12 in the gut. People with G/G or A/G genotypes are recommended to “Optimize Intake” because they may have lower levels of B12. Eating foods rich in vitamin B12 can promote healthy levels of B12, especially for those over the age of 50. People with the A/A genotype should “Stay Balanced” and maintain a healthy diet. The studies we report observed associations between vitamin B12 levels and particular genotypes; however, that does not mean that your levels are out of balance. You should ensure that you are eating a healthy diet and discuss this result with your physician.

YOUR RESULTS
Gene Your results Effects
FUT2 AA Higher levels of B12

Conclusion : Stay balanced. People with your genotype are less likely to have lower blood levels of vitamin B12. So a diet high in B12 is not your priority.

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@firemonkey Did you get a 23andme test and then pay extra to this geneticoncept site to analyse the data for you?
Was it cheaper than the £180 specific test for mthr?

It is probably better to get an overall 23andme test and pay extra for websites to analyse various things than individually pay over and over again for a company to analyse your saliva individually, perhaps @Green

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@Green It is £129 for a 23andme test that gives you the data plus $96 for geneticoncept test using 23andme data, which includes pharmacogenomic/health/ nutrition etc reports.

Thus £20 extra for loads of reports and analysis more. The pharmacogenomics analyses which antipsychotic medications are not/suitable. as well.

Mine. Never quite sure how to interpret this.

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@labratmat.

I think it’s all included in one off price of £180. That’s the impression I remember reading from the site. They say you don’t have to go through a 3rd party to get results and I’m sure £180 is all you pay. I’m not sure though.

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It does seem a bit simple, but I guess the metabolism is how the drug is processed in the body meaning that a high metabolism would mean it is either processed quickly or it speeds up your metabolic rate?

It is a pity it doesn’t go into more detail like associated weight gain chance, or risk of akathisia.

@firemonkey

Can I ask how the nutritional reports look like? Does it give details on food allergies or food reactions at all? How about exercise recommendations, what does that look like please?

Nutrition reports

CARBOHYDRATES METABOLISM

Subreports :

Elevated blood sugar (insulin sensitivity)
Insulin sensitivity response to training
Carbohydrate needs post-workout
Response to chromium picolinateNew!

FAT METABOLISM

Subreports :

Saturated fats
Monounsaturated fats
Polyunsaturated fats

VITAMINS PROFILE

Subreports :

Vitamin B6
Vitamin A
Vitamin C
Vitamin D
Vitamin E
Vitamin B12

FOLATE METABOLISM

LACTOSE INTOLERANCE

GLUTEN INTOLERANCE

TESTOSTERONE OPTIMISATION SYSTEM

CAFFEINE SENSITIVITY

HUNGER AND APPETITE CONTROL

Green tea response for fat loss

Training

STRENGTH VS ENDURANCE

Subreports :

Muscle fiber type composition
VO2Max
Overall endurance capacity
Overall strength capacity
(Also covers the notion of intensity and volume)

RECOVERY AND TRAINING FREQUENCY

TESTOSTERONE RESPONSE TO TRAINING

LACTATE THRESHOLD

HYPOXIC TRAINING RESPONSE

MUSCLE HYPERTROPHY

STEADY STATE CARDIO VS HIIT TRAINING (for fat loss)

INJURY PREVENTION

Subreports :

Tendon Injury
Ligament Injury
Disc Injury
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My doctor prescribed 5mg for the first few months, to bring levels back up, then 500mcg after that.

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