Efficacy and safety of sulforaphane in schizophrenia: a systematic review and meta-analysis of randomized controlled trials

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I use this

https://www.iherb.com/pr/source-naturals-broccoli-sprouts-extract-60-tablets-125-mg-per-tablet/132858

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Hi. What dosage do you take ? I tak clozapine, is sulforaphane good with clozapine ? What improvements do you notice when on it ?

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I just take the recommended 2 tablets in the morning.

Probably not a good idea with clozapine unfortunately.

A.I. says this :

Sulforaphane may interact with clozapine, so caution is advised. Always consult your prescribing doctor before combining them.

Here’s what the evidence suggests:

  • Clozapine is metabolized primarily by the CYP1A2 enzyme, and sulforaphane may influence this pathway.
  • Sulforaphane has been shown in animal and lab studies to inhibit CYP1A2, which could increase clozapine levels in the body, potentially raising the risk of side effects like sedation, seizures, or agranulocytosis.
  • However, its precursor, glucoraphanin, may actually induce CYP1A2, which could lower clozapine levels and reduce its effectiveness.
  • These effects are theoretical and not confirmed in humans, but the interaction is rated as moderate in likelihood and significance.

Given clozapine’s narrow therapeutic window and serious side effect profile, even theoretical interactions should be taken seriously. If you’re considering sulforaphane for its antioxidant or neuroprotective properties, your doctor might suggest safer alternatives or monitor your clozapine levels more closely.

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