Or do they just block most of the dopamine?
From studies I read it depends on the AP and its dose. Also AP don’t decrease dopamine but instead block mostly d2 dopamine receptors. Since dopamine is needed for movement I am sure that meds don’t block all the dopamine and its receptors. Studies I read say Risperidone, Zyprexa block up to 80% of d2 receptors while Haldol even more and Clozapine the least 30-40%.
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Its a mystery for me as to why Clozapine is the most effective AP yet it blocks the least amount of d2 dopamine receptors. I wish I knew why.
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Not sure but I think clozapine is every kind of agonist, antagonist, partial agonist etc.
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So less negatives on clozapine?
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One pdoc actually wanted me to try Clozapine for negative symptoms but my other pdoc said no it won’t help and it will cause much more weight gain and side effects, sometimes serious like heart damage. For Clozapine you need to do weekly blood tests for 6 months then every 2 weeks for 6 months then monthly forever as it could damage the immune system. Its used as a last resort AP for treatment resistant sz. So I refused.
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For now I am in the process of trying to be on Vraylar.
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Good luck with it I hope it works for you
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Vraylar, Abilify, Rexulti and maybe Caplyta? are partial dopamine agonists so they don’t fully block d2 receptors unlike all the other APs. They increase dopamine where and when its low while decreasing it where and when its high.
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Partial dopamine agonists dont work for me
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Yea I think they’re less effective than full antagonists.
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