Dementia in severe, extremely treatment-resistant schizophrenia is a distinct cognitive syndrome that is not adequately explained by Alzheimer disease (AD), other neurodegenerative dementias, antipsychotic exposure, cardiometabolic risk factors, poor effort, premorbid intellectual disability, or long-term institutionalization. These study results were published in JAMA Psychiatry.
Researchers conducted a retrospective cohort study to characterize clinical, cognitive, and genetic features of dementia in individuals with severe, extremely treatment-resistant schizophrenia.