Could a antihistamine be helpful going off zyprexa?

Medications
1

They say zyprexa has the highest affinity for the H1 receptors of all the ap’s. Could a antihistamine somehow alleviate going off zyprexa? Particulary I’m thinking about sedation(sleep) since zyprexa excerts most of it sedation through h1 receptor.

I did try with a antihistamine called valergan many years ago, but it just paralyzed my body while my brain was still awake when I tried going to sleep. But I guess different antihistamines excert different effects, so I might be inclined to try another one.

Maybe cut back from 7.5mg to 2.5mg zyprexa and take a antihistamine. The goal is decent sleep.

2

I’m on hydroxyzine. It is basically an antihistamine.

1 Like
3

Benadryl is the most sedating histamine they say.

You can buy the generic version in the sleep aid Dept much cheaper it’s called diphenhydramine k it’s the same thing look on benadryl bottle ingredients it’s exactly what it is

1 Like
4

Yes but you build rapid tolerance to antihistamines unlike how you do with antipsychotics. Histamine isn’t the entite picture it’s probably only going to work well for a week or two. Taking antihistamines is going to have feedback loops to hormones which aren’t favourable

1 Like
5

Adding simple regular exercise works better. I went from sleeping 10 hours a night to 8 or less with less naps adding exercise.

1 Like
6

try orexin antagonist drugs (suvorexant, lemborexant,Daridorexant) it have no dependence or tolerance and doesn’t cause weight gain according to researches.

1 Like
7

I’m also on hydroxacine 25mg doesn’t do much for me.