Before antipsychotics I used benadryl for roughly 3 years, at a small dose every night. to help with sleep from crazy endless anxiety thoughts at night, after awhile I realized It indeed DID have anti anxiety and a bit of anti depressant qualities to it. so, id say the answer is yes, however, I’m not sure what if it would have counteraction with other meds, cuz that’s all I was taking before schiz. hit me hard (i suffered with extreme anxiety, paranoia, depression before sciz.) So Id check with your doctor to see if that’s OK . hope my post made some kind of sense.