As the title suggests, we, my dad, psychiatrist, and I, have been mixing Haldol, a first generation antipsychotic, with Caplyta. This has led to an abundance of help with combating weight gain. But another, perhaps more imperative result is that the concoction has dramatically helped my negative symptoms, to the point of nominal to zero symptoms. This is particularly peculiar because the negative symptoms have always been extremely hard for me to fight. This knowledge, though, has been ascertained by my psychiatrist and the company of Caplyta, that now my case is a study in process. Just thought I’d share since I am doing extremely well with my schizophrenia symptoms, both postitive and negative symptoms. Hopefully I can promulgate this knowledge to many more schizophrenics also.
John.I’v been helped tremendously by mixing the old 1. gen Clopixol with the sec gen. Seroquel for the positives and side effects but at the same time I’ll say that this combo hasn’t improved the negatives or cognition that much. So your story gives all our sufferes.of negatives and cognitives symptoms a new hope. So I’m looking forward to read the results from the study.
Haloperidol was a nightmare to me. I would sleep all night and wake up tired. I had just enough energy to walk to a corner shop and I needed to lay down to rest. Also haloperidol caused parkinsonism to me
I’m one off those old guys who has a good impression off oldstyle antipsychotics. I don’t want to offend anybody with my opinion but that’s what I think.
Its particularly the case with the newer gen 2 antipsychotics. Some people receive the same effects of the conglomeration of medications as I do with Vraylar, though, when I took it, I did not receive any help whatsoever, with either positive or negative symptoms. Indeed, I was sent onto another psychotic break, making it the third in two years. But Caplyta has proved very differently, but not together the answer. It helps particularly with the negative symptoms of which I was suffering dearly. But the Haldol is diametrically opposed to Caplyta, but we think thats where it works. For the positive symptoms is helped by the Haldol, and the negatives, by the Caplyta.
I’m sorry to hear of your experiences with Haldol, though, I must say I have very similar side effects, and even some parkinsonism in my hands and lower extremities.
What you tell us really offers hope to all your fellowsufferes including me.
It does indeed. I was able to hold down a full-time job, talk to girls (I’m 20), and get my permit all while on this concoction.
“This led researchers such as Herbert Meltzer to propose that the differential antipsychotic effect of clozapine is related to its high 5-HT2/D2 ratio.”
“5HT2A antagonism can increase dopaminergic neurotransmission in the nigrostriatal pathway, reducing the risk of extrapyramidal symptoms. It could also theoretically improve negative and cognitive symptoms in schizophrenia by increasing dopamine release in the prefrontal cortex.”
Capylta is new-gen medication with strong affinity at 5th2a receptor.
Haloperidol as a fga has weak affinity for 5th2a. Hdol is off patent so they could easily recombined this medication to create a formula. Or even due to fgas weak affinity for 5th2a suggest things like augmentation of people in TRS with Capylta.
Theoretically it could also offset some of the extrapyramidal side effects of Hdol.
Interesting as there is therapeutic relevance to the combination but in my head it is basically just turing a fga into an sga by adding an sga. Why not just use an sga in the first place. Maybe there is something I am missing here that would come out on research.
Obviously there is a logic that you could see benefit as you were already on haldol but if people do well on an second generation antipsychotics. SGAs already having 5th2a antagonism then this combination probably isn’t going to do anything special.
Interesting none the less especially for anyone out there is already taking haloperidol, who are TRS or who can’t come off haldol and swap to an sga for whatever reason.
Caplyta also affects D1 receptor and is a minor D2 agonist as well as antagonist. There is speculation that it also affects the glutamatergic system.
Rapid dissociation from D2 receptors is another proposed mechanism for the features seen in sga i.e. lower side effects. It is possible that by acting as competitive antagonist to haldol that it reduces the side effect profile of hdol that way also. I actually had the idea that taking medication once daily would be advantageous for eps but when I went to search in the literature I saw the opposite that LAIs were actually favourable to once daily. Rapid dissociation would be in line with that thinking though but yeah. Idk if LAIs show increased results due to adherence or not.
Capylta also works as an SSRI so it’s going to help negatives there as adjuctive SSRI. I didn’t know it acts on the glutamatergic system.
It’s a dopamine modulator with high 5th2a affinity, SSRI function and glutamatergic activity. It’s actually a bit more novel then I thought. Kind of makes sense that you would pair it with the most side effect riddled drug still in use.
I’m not a scientist but I agree in that some 1. gen antipsychotics cause more eps than 2.gen antipsychotics but at the same time keep in mind that most 1.gen antipsychotics are less prone to cause weight gain. I’ve found the golden spot for my treatment namely Seroquel 900 mgs with 500 mgs LAI clopixol every 3 weeks.