Combining antipsychotics

My care coordinator talks about me taking another antipsychotic alongside olanzapine - either as a pill or a depot injection. Does anyone else take more than one antipsychotic and if so which ones?

Thank you
PFL X

3 Likes

I take Geodon and Latuda. Both orally.

2 Likes

I’m on high dose of olanzapine and a low dose aripiprazole. I’m not sure if adding the aripiprazole has had any effects on paranoia etc, but it does seem to make me a bit less tired and a bit less hungry compared to olanzapine alone. I’ve lost some weight without any effort just by adding the aripiprazole which is good

2 Likes

I take 300mg Clozaril and 60mg Latuda; I’m treatment resistant and I finally feel better on this combo.

5 Likes

I would not recommend doing this, years ago I switched to a different AP without letting the first one wear off first, I got so ill I nearly screamed. I was in excruciating pain mentally.

I take three: Risperdal Consta injection, Geodon and Seroquel. I was treatment resistant all my life. This three med combo works great for me. I am sza.

5 Likes

What were your symptoms, may I ask? Pain how?

I take 600 mg Clozaryl and 4 mg Haldol. I’m thinking of trying something new though.

I did
It was very useful in getting me well and it kept me well
I think they do it for a short while
A year or so maybe less
Helpful generally
Don’t be afraid of it, it’s just to get the best out of your recovery

Saphris and abilify

Thank you everyone

PFL x

3 Likes

It is hard to explain, there had to be something extremely wrong in my brain for me to feel that way, it was a very sick feeling mentally, like I said I almost screamed.

2 Likes

I take abilify 7.5 mg, and I take clozapine 400mg.

I was on Abilify 400mg injection and 800mg Seroquel oral… they worked pretty well together for me.

I take amisulpride 200mg and olanzapine 2,5mg. The two work well for me. Amisulpride helps with positive symptoms and olanzapine with negative symptoms.

That’s a lot of Seroquel… my 100 sedates me … I’m such a wuss

I take 4. Geodon, Latuda, Clozaril and sometimes Haldol. I’m treatment resistant. I also get ECT for my psychosis. They just added the Haldol as a PRN because I hear voices at night. This illness sucks. :sun_with_face:

2 Likes

depot is better go to blood directly and in portions along long time
oral i doubt they reach their site !!! why ?
cause they need absorption first which is not easy for very lipophilic material so about ~~50% absorbed
then pass through liver w is called first pass effect they
afterthat about 10-20-30% go to brain w is not enough to exert their effect
they should increase the doses to maintain the same effect increasing doses usually combined with higher side effects w is not good!!!
depot is better less dose less side effect and go to brain directly!

I used many drugs in combination with each other. I combined several drugs with Aripiprazole like, Risperidone, Amisulpride, Quetiapine, ziprasidone, Asenapine and Paliperidone, Of course I did not take all of them at once, but combined one or may be two of them with Abilify. Luckily I never had any side effects for using them. Now I am taking Lurasidone with Aripiprazole and I think this is the best combination I ever had.

I take 15mg risperidone and 45mg haldol…