what make clozapine superior to other atypical antipsychotics regarding its potency on symptoms and effecaicy specially in treatment resistant schizophrenia?
what is the difference in the mechanism of action of clozapine from other atypical antipsychotics?
It is just the best. 
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This title is hilarious, just so you know as a non-native speaker I think 2 word titles using the words superiority or supremacy can come across wrong without context.
Anyway. Pretty sure it’s the D2/5th2a ratio.
I didn’t actually know it was a inverse agonist at 5th2a, how fancy!
From skimming this paper I think they say it’s the norephinephrine ɑ-2 receptor antagonism?
Obviously the dumb answer is that it’s the chemical structure and the unique receptor binding profile. I don’t think anyone actually knows we just know clinically that it is better. People don’t know how antipsychotics work so consensus on pinning down exactly how clozapine was better would be be a step forward from that I imagine. Still my limited knowledge and assumption is that its got something to do with D2/5th2a ratio? Maybe try reading around that in the literature and see if you can come up with anything interesting
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Good old clozapine. If I could have gotten past all the passing out and other side effects I would still be taking it .
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No other med strip mines your white cells like this one does.
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No other med makes you drool so much that you choke on it!
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