Sarcosine wasn’t good for me. After three month it gets me nervous. Maybe too much glutamate in brain.
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Taurine works for me. It makes me calm.
My new batch of broccoli sprout supplement arrived today. Good old iherb.com !
I hope there’s no long term bad side effects as it helps so much.
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I’m going to try a double dose for a while and see what happens. The single dose as suggested on the bottle is great. So maybe it’ll make things worse. But in the interests of Science I’ll give it a go.
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Ok. Taking double the dose acts as a relaxant. I feel very mellow. Lets see how long I remain mellow…
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Yeah… I feel too sedated. But it’s good to know that I can sedate myself with this stuff if I need to.
So that’s 4 pills.
I might try 3 pills tomorrow.
With 2 pills I had some get up and go and no anxiety or distress. So 2 pills , the recommended dose is probably best.
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I kind of had a messed up day on 4 pills really. Just this uneasy feeling that something is wrong all day.
I’ll go back to 2 pills and not experiment with 3 pills as I want to be able to tell my psychiatrist something positive in a weeks time.
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@twinklestars first off, it’s a little off-topic though, I’m sorry for that. I really like the contribution you make to this forum in the news section and how easy you make understand difficult stuff into easy reading what’s been said in study’s for people that have a hard time interpreting stuff in study’s, you’re really smart. I myself don’t have that problem but I love the way you sum up the important stuff and I don’t even bother clicking links anymore and read the summary of study’s you post.
Though, what I do want to point out to is the way you approach some of the stuff I read about your way of doing things. Like for example the way you approach supplementing with “things” that might work or is proven to work on some individuals but you seem to make a loop and try it with certain (mainly biological/natural) foods/drinks in order to vial the study’s to get some relieve of your symptoms.
In my opinion you don’t do yourself a favor in growing and drinking stuff that might been of help.
The one thing I’ve learned it’s easier to know if something might help is to buy and try reliable supplements/drugs with the right dosage in order to know if it might help or not. My biggest success/example from the past in 2010 is Sarcosine… I already ate a lot of chicken and always have been a big fan of chicken which contains quite some natural Sarcosine but the big change came after supplementing with pure Sarcosine.
What I’m trying to say is don’t try getting sarcosine, sulphurophane or betain or whatsoever out of food/drinks, it’s better to expose yourself to high quality in supplement form (like in the study’s).
The reason I’m saying this to you is that I really trust you instead of people that are sensitive to placebo effects. (Not that I want you to be guinea pig for me but it’s better to have insight in a bright mind like yours instead of people just trying stuff and report on it)
And btw I myself am pretty much symptom free for a really long time except negative symptoms.
Regards,
Young
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I appreciate what you are saying, and it’s true that just eating broccoli won’t get you anywhere near the level of sulforaphane used in the study. It’s harder to say with sprouts, because they vary. But there are sources on the web where you can make an educated estimate. I actually do plan to buy the supplement used in the study (Avmacol) after it is published, and when I have money.
I haven’t really looked into the amounts of betaine in beet juice vs the supplement doses used in schizophrenia. Do you know what the supplemental doses are? I was going to hold off on that one because it seems like it is people with a specific genetic marker that benefit most. Beet juice has other benefits though, it also lowers blood pressure.
TBH I have no idea about the Betaine dosage, I haven’t looked into study’s. I might try Avmacol myself too but yeah it’s too early and expensive to give it a fair chance. Besides I stopped searching, buying and trying supplements. In the past when I was really sick Sarcosine was the one magic bullet that really had changed a lot for me out of the dozens of supplements and drugs I tried over the course of more than 10 years.
My biggest challenge right now is to find a solution for my years of ongoing sleeping problems. And it sounds and it’s contradicted but the one thing that really helps my sleep, mood and negative symptoms is alcohol so I’m pretty much “self-medicating” with it.
IDK, I have hopes that one of the chemically made negative/cognitive drugs currently in phase III will pass through and might change a lot for me.
Since you are way smarter than me, maybe it’s a good idea for you to take a 23andMe DNA Genetic Testing & Analysis test. I’m confident that you’ll know how to supplement after you have the outcome of the test results.
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Hmm. Alcohol can be dangerous long term in large quantity - as I’m sure you know. I used it too though so I get it. Alcohol acts on GABA, among other things. I dunno, probably anything I could suggest you’ve already tried.
Sleep is hard. Lumateperone does seem like it has some promise there though. And Minerva also has a med for insomnia in their pipeline.
More off topic, but I found the reference to genetics and betaine.
Furthermore, a CHDH variant, rs35518479, was identified as a cis-expression quantitative trait locus (QTL) for CHDH expression in postmortem brains from schizophrenia, allowing genotype-based stratification of schizophrenia patients for betaine efficacy.
So it seems if you have this variant, betaine might be particularly helpful. But I still don’t know the dosage.
If either or both of you are looking for a nice gabaergic to potentially replace alcohol, you might want to look into gabapentin. It works really well on nervous pain in general, and it is also a great anxiolytic, kind of like benzos but without the sedation. I use gabapentin, and it has turned my life around in terms of getting a handle on my negative symptoms as well as the akathesia from the antipsychotics. A pro-drug form of gabapentin is pregabalin, marketed as Lyrica, which I haven’t tried but is very popular these days as an anxiety treatment…
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I’ve been taking it for about a montth and a half. I think it’s now beginning to make me feel “fuzzy headed”.
It’s doing a good job of getting rid of anxiety and distress for me though. I no longer need to use L-theanine.
I can probably put up with being a bit fuzzy headed. For now anyway.
Hmmm… Actually the fuzzy head feeling may very well be due to withdrawal from stopping L-theanine. We’ll see.
Is there a reason you don’t want to take both?
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It looks like I might have to.
I just thought I didn’t need L-theanine anymore as my anxiety was reduced. But it looks like it straightened out my thoughts more than I realised.
I actually took it today and felt better.
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I took broccoil sprouts extract yesterday and for the first 2 hours it was ok, but then I started yawning and a severe depression hit. I took the second dose anyway to see if it could help, but alas the depression continued.
It reminds me of the dead feeling i got from taking CBD oil which I also found deadening.
An expensive trial and error of BS Extract, but I won’t be taking that again. 
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What type of broccoli sprout extract did you take? What brand?
source naturals 250mg.