I just can’t concentrate. Not one bit. It is really distressing.
My AP seroquel has significant anticholinergic activity at the dose I take. It has been postulated this property causes cognitive dysfunction.
In layman’s terms this med totally gives me a fuzzy head.
I have read latuda is a cognitive sparing AP. Seriously considering trying to switch meds some time next year. I had seroquel withdrawals before but I kinda want to make the change to latuda in a fast crossover.
Acetylcholine is used for learning and memory. I think anti-cholinergics block acetylcholine.
seroquel is medium anticholinergic compared to clozapine and olanzapine. remember that these meds are only tested over a term of several weeks to months, meaning no one knows what effect seroquel has on cognition long term. from what ive read cognitive dulling issues on seroquel have more of an impact at a higher dose distributed over a longer period of time. i think this effect tends to be greater in the elderly as well as those who are concurrently on other anticholinergic medications. there is also the possibility that your brain has adapted to the anticholinergic blockade over a long period of time, increasing the production of or sensitivity to acetylcholine over time and boosting your memory overall, this is why memantine is said to improve cognition, but this effect is only seen in that drug typically,
also consider risperidone, it doesn’t make you fuzzy, but man boobs
Had a bad dystonic reaction to respiridone. Can’t have it again.
Hey, seroquel used to really help me pay attention. and its great for anxiety, i can take 100mg and my anxiety gets a lot better, WAIT! seroquel is supposed to be an antihistamine at that dose! Yes, but it still hits the adrenergic receptors. I think if we could come up with a med that just regulates those receptors we would have side effect free aps which actually work, without most of the effects being placebo as I believe they currently are. Think about it, so many ppl have given in to the cliche, take tablet = feel better. headache, take a tablet, erectile dysfunction, theres a tablet for that too. So for mental illness ppl think whatever ails them has GOT to be cured by some kind of tablet handed to them by someone in a lab coat. the cycle continues
Off the top of my head, Risperdal, Abilify, Vraylar, and Latuda were best for cognition for me. The higher the dose, the worse the cognition gets though. It’s very complicated though. Because if you’re psychotic, it’s really hard to study or learn anything.
you know, i was actually starting to have cognitive problems before starting antipsychotics, and they seemed to go away after i started abilify. i probably shouldnt question a blessing
I have seen a couple of my doctors for many years. One of them wants me to take Lecithin and Phosphatidylserine so that my body can make more acetyl choline.
I am a freak in the following sense: I have been on trilafon (perphenazine) for nearly 50 years and have no case of TD.
compared to lurasidone seroquel has weaker d2 blocking, that might mean your cognition would be preserved more on seroquel if d2 blocking is a significant factor for your unique neutoransmission. i would stick with seroquel and go down to 300-400 and see if the situation is any better. if not maybe consider trying latuda, all with your doctor’s blessing