i would just be curious i am taking these two antipsychotics and i would like to leave one to take only one.
I’ve been on Quetiapine 400 x 2 and Geodon 80 x 2 for a long time - over a decade. I haven’t had a single psychotic break since. I thought the Geodon was doing all the work, but then I didn’t get my Quetiapine for a few days, and I was more jittery than I cared to be. Some people say Quetiapine is too sedating, but I don’t get that from it.
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Amisulpride - in high doses are antipsychotic in low doses it’s good for negative symptoms / anhedonia…
Quietapine - in high doses antipsychotic, in low doses good for sleep and depression.
So it depends on your symptoms.
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amisulpride is more effective than quetiapine for overall improvement, its 2nd best after clozapine
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My understanding is that Amisulpride is the 2nd “best” antipsychotic, but everyone is different so talk with your pdoc about your options.
That’s why I have to take more than just amisulpride -
because if I take my usual dose (200-400mg) I don’t have as much psychosis but get negative symptoms
but if I take too low a dose (100mg or less) I’d get psychosis
So my one pdoc prescribed I take 5mg olanzapine as well for depression (which could also be negative symptoms).
That’s good to know amisulpride is ranked 2nd after clozapine - it has worked very well for me! 
200 mg good for negative symptoms and depression? or is it even an antipsychotic effect?
Strange, but my Pdoc plans to put me on exactly 5 mg zyprexa and 200 mg amisulpride, cause i mostly have negative symptoms.
I think you should talk with your psychiatrist about stopping quietapine so you just take 2 ap’s and then find the right level of medication.
I lower doses (up til 200 mg) it’s primarily meant to alleviate negative symptoms. Above 200 mg it also work against positive symptoms.
I read that in small doses it’s regulating dopamine, but blocks it very effectively in high doses-
I have taken Amisulpride for 2 years, and it basically got rid of 99% of my positive symptoms.
Been on 6 different AP’s. This one is the best for me so far.
My prolactin is three times higher than high range number, but benefits outweigh risk according to the doctor.
I am hopeful it will work well for years to come.
i am on amisulpride (250 mg / day) , clozapine (25 mg / day) , sertraline (50 mg ) and bupropion 300 mg extended release.
